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Cystatin 1 (CST1)

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Cystatin SN; Salivary cystatin-SA-1

Cystatin 1 (CST1)
CCC J330
HGNC 2473
PubMed 9007972
UniProt P01037
Wiki CST1
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes.
CST1 is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ330Hu01 Recombinant Cystatin 1 (CST1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ330Hu01 Polyclonal Antibody to Cystatin 1 (CST1) WB; IHC; ICC; IP.
LAJ330Hu71 Biotin-Linked Polyclonal Antibody to Cystatin 1 (CST1) WB; IHC; ICC.
LAJ330Hu81 FITC-Linked Polyclonal Antibody to Cystatin 1 (CST1) WB; IHC; ICC; IF.
MAJ330Hu21 Monoclonal Antibody to Cystatin 1 (CST1) WB
MAJ330Hu22 Monoclonal Antibody to Cystatin 1 (CST1) WB; IHC; ICC; IP.
MAJ330Hu23 Monoclonal Antibody to Cystatin 1 (CST1) WB
MAJ330Hu24 Monoclonal Antibody to Cystatin 1 (CST1) WB; IHC; ICC; IP.
Assay Kits SEJ330Hu ELISA Kit for Cystatin 1 (CST1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family."Gene 61:329-338(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Purification, molecular cloning, and sequencing of salivary cystatin SA-1."J. Biol. Chem. 263:9381-9387(1988) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes."Biol. Chem. Hoppe-Seyler 369:191-197(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S."J. Biochem. 110:648-654(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting."Proteomics 2:112-120(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of a new cysteine proteinase inhibitor of human saliva, cystatin SN, which is immunologically related to cystatin S."FEBS Lett. 198:145-149(1986) [PubMed] [Europe PMC] [Abstract]
  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry."J. Am. Soc. Mass Spectrom. 21:908-917(2010) [PubMed] [Europe PMC] [Abstract]