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Vacuolar Protein Sorting 4A (VPS4A)

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SKD2; SKD1; VPS4; VPS4-1; SKD1A

Vacuolar Protein Sorting 4A (VPS4A)
CCC J338
HGNC 13488
MGI 1890520
PubMed 16174732
RGD 628810
UniProt Q9UN37
Wiki VPS4A
Vacuolar protein sorting-associated protein 4A is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really a yeast Vps4 ortholog.
Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 4A (VPS4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 4A (VPS4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 4A (VPS4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 4A (VPS4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 4A (VPS4A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 4A (VPS4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 4A (VPS4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 4A (VPS4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 4A (VPS4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 4A (VPS4A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 4A (VPS4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 4A (VPS4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 4A (VPS4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 4A (VPS4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 4A (VPS4A) ELISA Kit Customized Service Offer
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  2. "Comparative sequence and expression analyses of four mammalian VPS4 genes."Gene 305:47-59(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking."Mol. Biol. Cell 11:227-239(2000) [PubMed] [Europe PMC] [Abstract].
  7. "Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding."Cell 107:55-65(2001) [PubMed] [Europe PMC] [Abstract]
  8. "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins."J. Cell Sci. 114:2395-2404(2001) [PubMed] [Europe PMC] [Abstract]
  9. "The protein network of HIV budding."Cell 114:701-713(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins."Proc. Natl. Acad. Sci. U.S.A. 100:12414-12419(2003) [PubMed] [Europe PMC] [Abstract]
  11. ErratumProc. Natl. Acad. Sci. U.S.A. 100:152845-152845(2003)
  12. "ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles."J. Cell Sci. 117:1699-1708(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Structural and mechanistic studies of VPS4 proteins."EMBO J. 24:3658-3669(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis."EMBO J. 26:4215-4227(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B."Nat. Struct. Mol. Biol. 15:1278-1286(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Essential role of hIST1 in cytokinesis."Mol. Biol. Cell 20:1374-1387(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Biochemical analyses of human IST1 and its function in cytokinesis."Mol. Biol. Cell 20:1360-1373(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15."J. Virol. 85:7153-7161(2011) [PubMed] [Europe PMC] [Abstract]
  21. "ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4."Nat. Cell Biol. 16:550-560(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A."Proc. Natl. Acad. Sci. U.S.A. 102:13813-13818(2005) [PubMed] [Europe PMC] [Abstract]
  23. "ESCRT-III recognition by VPS4 ATPases."Nature 449:740-744(2007) [PubMed] [Europe PMC] [Abstract]
  24. "Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding."Dev. Cell 15:62-73(2008) [PubMed] [Europe PMC] [Abstract]