Cornulin (CRNN)

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SEP53; C1orf10; DRC1; PDRC1; 53 kDa putative calcium-binding protein; Squamous epithelial heat shock protein 53; Tumor-related protein; 58 kDa heat shock protein

Cornulin (CRNN)
Cornulin is a member of the 'fused gene' family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation.
The C1ORF10 cDNA encodes a deduced 490-amino acid protein with 1 transmembrane domain, an N-terminal EF-hand calcium-binding motif of about 90 amino acids that shares 25 to 35% identity to human S100 calcium-binding proteins, and a conserved consecutive repeat sequence of about 60 amino acids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ341Hu01 Recombinant Cornulin (CRNN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ341Hu01 Polyclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IP.
MAJ341Hu21 Monoclonal Antibody to Cornulin (CRNN) WB; IHC; ICC; IP.
Assay Kits SEJ341Hu ELISA Kit for Cornulin (CRNN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cornulin (CRNN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cornulin (CRNN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cornulin (CRNN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cornulin (CRNN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cornulin (CRNN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cornulin (CRNN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cornulin (CRNN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cornulin (CRNN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cornulin (CRNN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cornulin (CRNN) ELISA Kit Customized Service Offer
  1. "Novel human esophagus-specific gene c1orf10: cDNA cloning, gene structure, and frequent loss of expression in esophageal cancer."Genomics 69:322-330(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The human oesophageal squamous epithelium exhibits a novel type of heat shock protein response."Eur. J. Biochem. 268:5343-5355(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Chromosome 1 open reading frame 10 (C1orf10) gene is frequently down-regulated and inhibits cell proliferation in oral squamous cell carcinoma."Int. J. Biochem. Cell Biol. 37:1641-1655(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Cornulin, a new member of the 'fused gene' family, is expressed during epidermal differentiation."J. Invest. Dermatol. 124:990-997(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease."Ann. Otol. Rhinol. Laryngol. 115:47-58(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury."FEBS J. 273:1930-1947(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Decreased expression of gene cluster at chromosome 1q21 defines molecular subgroups of chemoradiotherapy response in esophageal cancers."Clin. Cancer Res. 13:912-919(2007) [PubMed] [Europe PMC] [Abstract]