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Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1)

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Cysteine-Rich Motor neuron 1; Chordin-Like; Cysteine-rich repeat-containing protein S52

Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1)
CCC J344
HGNC 2359
MGI 1354756
PubMed 22427856
RGD 1308710
UniProt Q9NZV1
Wiki CRIM1
Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed sonic hedgehog protein (SHH). Dorsally expressed factors, such as members of the bone morphogenic protein and transforming growth factor-beta families, can repress the induction of these neurons.
CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival . Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ344Hu01 Recombinant Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ344Hu01 Polyclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) WB; IHC; ICC; IP.
MAJ344Hu21 Monoclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) WB; IHC; ICC; IP.
Assay Kits SEJ344Hu ELISA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis."Mech. Dev. 90:181-193(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface."J. Biol. Chem. 278:34181-34188(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo."Mech. Dev. 119:165-175(2002) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]