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Coenzyme Q7 Homolog, Ubiquinone (COQ7)

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CLK-1; CAT5; Timing protein clk-1 homolog; Ubiquinone biosynthesis protein COQ7 homolog

Coenzyme Q7 Homolog, Ubiquinone (COQ7)
CCC J361
HGNC 2244
MGI 107207
PubMed 18808426
RGD 2381
UniProt Q99807
Wiki COQ7
COQ7 is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Transcript variants have been described for this gene, but their full-length sequences have not been determined.
The protein shares 85%, 89%, 53%, and 37% sequence identity with orthologs from mouse, rat, C. elegans, and S. cerevisiae, respectively. COQ7 transfected into COS-7 cells shows a single band of about 25 kD by Western blot analysis. Northern blot analysis detected expression of a 0.9-kb COQ7 transcript in heart and skeletal muscle, with barely detectable expression in brain, placenta, liver, kidney, and pancreas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coenzyme Q7 Homolog, Ubiquinone (COQ7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coenzyme Q7 Homolog, Ubiquinone (COQ7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coenzyme Q7 Homolog, Ubiquinone (COQ7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coenzyme Q7 Homolog, Ubiquinone (COQ7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coenzyme Q7 Homolog, Ubiquinone (COQ7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coenzyme Q7 Homolog, Ubiquinone (COQ7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coenzyme Q7 Homolog, Ubiquinone (COQ7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coenzyme Q7 Homolog, Ubiquinone (COQ7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coenzyme Q7 Homolog, Ubiquinone (COQ7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coenzyme Q7 Homolog, Ubiquinone (COQ7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coenzyme Q7 Homolog, Ubiquinone (COQ7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coenzyme Q7 Homolog, Ubiquinone (COQ7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coenzyme Q7 Homolog, Ubiquinone (COQ7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coenzyme Q7 Homolog, Ubiquinone (COQ7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coenzyme Q7 Homolog, Ubiquinone (COQ7) ELISA Kit Customized Service Offer
  1. "Orthologues of the Caenorhabditis elegans longevity gene clk-1 in mouse and human."Genomics 58:293-301(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging."Mamm. Genome 10:1000-1004(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1."Science 275:980-983(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption." J. Clin. Invest. 123:5179-5189(2013) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis." Proc. Natl. Acad. Sci. U.S.A. 111:E4697-4705(2014) [PubMed] [Europe PMC] [Abstract]