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Citron (CIT)

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STK21; CRIK; Rho-Interacting,Serine/Threonine Kinase 21; Citron Rho-interacting kinase

Citron (CIT)
CCC J367
HGNC 1985
MGI 105313
PubMed 9792683
RGD 70878
UniProt O14578
Wiki CIT
CRIK can be expressed as at least 2 isoforms, one of which encompasses the previously reported form of citron in almost its entirety. The long form of CRIK is a 240-kD protein in which the kinase domain is followed by the sequence of citron. The short form, CRIK-SK (short kinase), is an approximately 54-kD protein that consists mostly of the kinase domain. CRIK and CRIK-SK proteins are capable of phosphorylating exogenous substrates as well as of autophosphorylation, when tested by in vitro kinase assays after expression into COS-7 cells. CRIK kinase activity is increased several-fold by coexpression of constitutively active Rho, while active Rac has more limited effects. Kinase activity of the endogenous CRIK is indicated by in vitro kinase assays after immunoprecipitation with antibodies recognizing the citron moiety of the protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Citron (CIT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Citron (CIT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Citron (CIT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Citron (CIT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Citron (CIT) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Citron (CIT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Citron (CIT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Citron (CIT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Citron (CIT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Citron (CIT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Citron (CIT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Citron (CIT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Citron (CIT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Citron (CIT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Citron (CIT) ELISA Kit Customized Service Offer
  1. "Evidence of association between bipolar disorder and Citron on chromosome 12q24."Mol. Psychiatry 10:807-809(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "KIF14 and citron kinase act together to promote efficient cytokinesis."J. Cell Biol. 172:363-372(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Dissecting the role of Rho-mediated signaling in contractile ring formation."Mol. Biol. Cell 17:43-55(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase."J. Cell Sci. 120:1859-1867(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase."FEBS Lett. 585:1260-1268(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]