≡

Cytoplasmic Linker Associated Protein 2 (CLASP2)

[Edit]

hOrbit2; CLIP-associating protein 2; Protein Orbit homolog 2

Cytoplasmic Linker Associated Protein 2 (CLASP2)
CCC J369
HGNC 17078
MGI 1923749
PubMed 24368809
RGD 619789
UniProt O75122
Wiki CLASP2
CLIP170 and CLIP115 are cytoplasmic linker proteins that associate specifically with the ends of growing microtubules and may act as anticatastrophe factors.
CLASP2 shares approximately 75% identity with the KIAA0627 protein. There are several CLASP isoforms due to alternative splicing. Northern blot analysis of mouse tissues detected highest expression of Clasp1 in brain, heart, and testis, while Clasp2 mRNAs were enriched in the brain. The Clasp2-beta transcript appeared to be brain-specific. Antibody injections suggested that CLASP2 is required for the orientation of stabilized microtubules toward the leading edge. The authors proposed that CLASPs are involved in the local regulation of microtubule dynamics in response to positional cues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytoplasmic Linker Associated Protein 2 (CLASP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytoplasmic Linker Associated Protein 2 (CLASP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytoplasmic Linker Associated Protein 2 (CLASP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytoplasmic Linker Associated Protein 2 (CLASP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytoplasmic Linker Associated Protein 2 (CLASP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytoplasmic Linker Associated Protein 2 (CLASP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytoplasmic Linker Associated Protein 2 (CLASP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytoplasmic Linker Associated Protein 2 (CLASP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytoplasmic Linker Associated Protein 2 (CLASP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytoplasmic Linker Associated Protein 2 (CLASP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytoplasmic Linker Associated Protein 2 (CLASP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytoplasmic Linker Associated Protein 2 (CLASP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytoplasmic Linker Associated Protein 2 (CLASP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytoplasmic Linker Associated Protein 2 (CLASP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytoplasmic Linker Associated Protein 2 (CLASP2) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts."Cell 104:923-935(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance."Neuron 42:913-926(2004) [PubMed] [Europe PMC] [Abstract]
  8. "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex."J. Cell Biol. 168:141-153(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells."J. Cell Biol. 169:929-939(2005) [PubMed] [Europe PMC] [Abstract]
  10. ErratumJ. Cell Biol. 171:393-393(2005)
  11. "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta."Dev. Cell 11:21-32(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment."Genes Cells 11:845-857(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function."Mol. Biol. Cell 17:4526-4542(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network."Dev. Cell 12:917-930(2007) [PubMed] [Europe PMC] [Abstract]
  15. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "An EB1-binding motif acts as a microtubule tip localization signal."Cell 138:366-376(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  21. "ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells."Proc. Natl. Acad. Sci. U.S.A. 107:18517-18522(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]