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Chromatin Modifying Protein 1B (CHMP1B)

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C18-ORF2; C18orf2; CHMP1.5; Vps46-2; Vps46B; Charged Multivesicular Body Protein 1b; Vacuolar protein sorting-associated protein 46-2

Chromatin Modifying Protein 1B (CHMP1B)
CCC J382
HGNC 24287
MGI 1914314
PubMed 17711858
RGD 1593500
UniProt Q7LBR1
Wiki CHMP1B
CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.The C18ORF2 gene encodes a deduced 199-amino acid protein with a predicted molecular mass of 22.1 kD. The protein is highly conserved across several species and shares 55% sequence identity with the PRSM1 gene (CHMP1A). RT-PCR analysis detected moderate expression of C18ORF2 in all tissues tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromatin Modifying Protein 1B (CHMP1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromatin Modifying Protein 1B (CHMP1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromatin Modifying Protein 1B (CHMP1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromatin Modifying Protein 1B (CHMP1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromatin Modifying Protein 1B (CHMP1B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromatin Modifying Protein 1B (CHMP1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromatin Modifying Protein 1B (CHMP1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromatin Modifying Protein 1B (CHMP1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromatin Modifying Protein 1B (CHMP1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromatin Modifying Protein 1B (CHMP1B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromatin Modifying Protein 1B (CHMP1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromatin Modifying Protein 1B (CHMP1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromatin Modifying Protein 1B (CHMP1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromatin Modifying Protein 1B (CHMP1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromatin Modifying Protein 1B (CHMP1B) ELISA Kit Customized Service Offer
  1. "C18orf2, a novel, highly conserved intronless gene within intron 5 of the GNAL gene on chromosome 18p11."Cytogenet. Cell Genet. 93:19-22(2001) [PubMed] [Europe PMC] [Abstract]
  2. "CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression."J. Cell Sci. 114:2383-2393(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The protein network of HIV budding."Cell 114:701-713(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins."Proc. Natl. Acad. Sci. U.S.A. 100:12414-12419(2003) [PubMed] [Europe PMC] [Abstract]
  6. ErratumProc. Natl. Acad. Sci. U.S.A. 100:152845-152845(2003)
  7. "The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B."Hum. Mol. Genet. 14:19-38(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A."Proc. Natl. Acad. Sci. U.S.A. 102:13813-13818(2005) [PubMed] [Europe PMC] [Abstract]
  9. "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex."Genomics 88:333-346(2006) [PubMed] [Europe PMC] [Abstract]
  10. "ESCRT-III recognition by VPS4 ATPases."Nature 449:740-744(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly."Mol. Biol. Cell 19:2661-2672(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Essential role of hIST1 in cytokinesis."Mol. Biol. Cell 20:1374-1387(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Biochemical analyses of human IST1 and its function in cytokinesis."Mol. Biol. Cell 20:1360-1373(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15."J. Virol. 85:7153-7161(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B."Nat. Struct. Mol. Biol. 15:1278-1286(2008) [PubMed] [Europe PMC] [Abstract]