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Chromatin Modifying Protein 2B (CHMP2B)

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DMT1; CHMP2.5; VPS2-2; VPS2B; Charged multivesicular body protein 2b; Vacuolar protein sorting-associated protein 2-2

Chromatin Modifying Protein 2B (CHMP2B)
CCC J384
HGNC 24537
MGI 1916192
PubMed 24158394
RGD 1306781
UniProt Q9UQN3
Wiki CHMP2B
CHMP2B encodes a component of the heteromeric ESCRT-III complex that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.The deduced 213-amino acid protein contains coiled-coil, Snf-7, and acidic C-terminal domains. Two minor transcripts of approximately 1.9 and 1.35 kb were also identified, suggestive of alternative 5-prime and 3-prime untranslated regions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromatin Modifying Protein 2B (CHMP2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromatin Modifying Protein 2B (CHMP2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromatin Modifying Protein 2B (CHMP2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromatin Modifying Protein 2B (CHMP2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromatin Modifying Protein 2B (CHMP2B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromatin Modifying Protein 2B (CHMP2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromatin Modifying Protein 2B (CHMP2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromatin Modifying Protein 2B (CHMP2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromatin Modifying Protein 2B (CHMP2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromatin Modifying Protein 2B (CHMP2B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromatin Modifying Protein 2B (CHMP2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromatin Modifying Protein 2B (CHMP2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromatin Modifying Protein 2B (CHMP2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromatin Modifying Protein 2B (CHMP2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromatin Modifying Protein 2B (CHMP2B) ELISA Kit Customized Service Offer
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  7. ErratumProc. Natl. Acad. Sci. U.S.A. 100:152845-152845(2003)
  8. "Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia."Nat. Genet. 37:806-808(2005) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "ESCRT-III recognition by VPS4 ATPases."Nature 449:740-744(2007) [PubMed] [Europe PMC] [Abstract]
  18. "ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)."Neurology 67:1074-1077(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)."PLoS ONE 5:E9872-E9872(2010) [PubMed] [Europe PMC] [Abstract]