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Chromatin Modifying Protein 4A (CHMP4A)

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SNF7; SNF7-1; Shax2; C14orf123; Charged Multivesicular Body Protein 4a; SNF7 homolog associated with Alix-2; Vacuolar protein sorting-associated protein 32-1

Chromatin Modifying Protein 4A (CHMP4A)
CCC J385
HGNC 20274
PubMed 18209100
UniProt Q9BY43
Wiki CHMP4A
CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression .
The deduced 223-amino acid protein has 3 coiled-coil regions, a basic N-terminal half, and an acidic C-terminal half.Northern blot analysis detected CHMP4A expression in all tissues examined, with highest levels in kidney, liver, skeletal muscle, and heart.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromatin Modifying Protein 4A (CHMP4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromatin Modifying Protein 4A (CHMP4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromatin Modifying Protein 4A (CHMP4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromatin Modifying Protein 4A (CHMP4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromatin Modifying Protein 4A (CHMP4A) ELISA Kit Customized Service Offer
  1. "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting."J. Biol. Chem. 278:39104-39113(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and function of human Vps20 and Snf7 proteins."Biochem. J. 377:693-700(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding."Cell 114:689-699(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The protein network of HIV budding."Cell 114:701-713(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins."Proc. Natl. Acad. Sci. U.S.A. 100:12414-12419(2003) [PubMed] [Europe PMC] [Abstract]
  9. ErratumProc. Natl. Acad. Sci. U.S.A. 100:152845-152845(2003)
  10. "CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms."Arch. Biochem. Biophys. 421:159-165(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1."J. Biol. Chem. 280:12799-12809(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis."EMBO J. 26:4215-4227(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Structure/function analysis of four core ESCRT-III proteins reveals common regulatory role for extreme C-terminal domain."Traffic 8:1068-1079(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Plasma membrane deformation by circular arrays of ESCRT-III protein filaments."J. Cell Biol. 180:389-402(2008) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "ALIX-CHMP4 interactions in the human ESCRT pathway."Proc. Natl. Acad. Sci. U.S.A. 105:7687-7691(2008) [PubMed] [Europe PMC] [Abstract]