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Choline Phosphotransferase 1 (CHPT1)

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CPT1; Phosphatidylcholine Synthesizing Enzyme; Cholinephosphotransferase 1; AAPT1-like protein; Diacylglycerol cholinephosphotransferase 1

Choline Phosphotransferase 1 (CHPT1)
CCC J389
HGNC 17852
MGI 2384841
RGD 1359283
UniProt Q8WUD6
Cholinephosphotransferase transfers a phosphocholine moiety from CDP-choline to diacylglycerol thus forming phosphatidylcholine (PtdCho) and CMP. This reaction defines the ultimate step in the Kennedy pathway for the genesis of de novo synthesized PtdCho.
CHPT1 belongs to the CDP-alcohol phosphatidyltransferase class-I family.Highly expressed in testis, colon, small intestine, heart, prostate and spleen. Also detected in kidney, skeletal muscle, pancreas, leukocytes, ovary and thymus. Weakly expressed in the brain, placenta and lung. Overexpressed in cancerous breast epithelial cell lines. Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Choline Phosphotransferase 1 (CHPT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Choline Phosphotransferase 1 (CHPT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Choline Phosphotransferase 1 (CHPT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Choline Phosphotransferase 1 (CHPT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Choline Phosphotransferase 1 (CHPT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Choline Phosphotransferase 1 (CHPT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Choline Phosphotransferase 1 (CHPT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Choline Phosphotransferase 1 (CHPT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Choline Phosphotransferase 1 (CHPT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Choline Phosphotransferase 1 (CHPT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Choline Phosphotransferase 1 (CHPT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Choline Phosphotransferase 1 (CHPT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Choline Phosphotransferase 1 (CHPT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Choline Phosphotransferase 1 (CHPT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Choline Phosphotransferase 1 (CHPT1) ELISA Kit Customized Service Offer
  1. "Cloning, genomic organization, and characterization of a human cholinephosphotransferase."J. Biol. Chem. 275:29808-29815(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Inhibition of cholinephosphotransferase activity in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog."J. Biochem. Mol. Toxicol. 19:289-297(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Differential expression of cholinephosphotransferase in normal and cancerous human mammary epithelial cells."Biochem. Biophys. Res. Commun. 297:1043-1048(2002) [PubMed] [Europe PMC] [Abstract]
  6. "The major sites of cellular phospholipid synthesis and molecular determinants of fatty acid and lipid head group specificity."Mol. Biol. Cell 13:3148-3161(2002) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]