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Carbohydrate Sulfotransferase 2 (CHST2)

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C6ST; GN6ST; Gn6ST-1; N-acetylglucosamine 6-O-sulfotransferase 1; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2

Carbohydrate Sulfotransferase 2 (CHST2)
CCC J392
HGNC 1970
MGI 1891160
PubMed 10049591
RGD 10049591
UniProt Q9Y4C5
Wiki CHST2
N-acetylglucosamine-6-O-sulfotransferases, such as CHST2, catalyze the transfer of sulfate from 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) to position 6 of a nonreducing N-acetylglucosamine (GlcNAc) residue.The predicted 530-amino acid CHST2 protein contains a hydrophobic region in the N terminus that may function as a transmembrane domain for a type II protein or as a Golgi retention signal.
These authors reported that GlcNAc-6-O-sulfotransferase cDNAs could be translated to yield a deduced 484-amino acid protein as well as a longer isoform. Northern blot analysis detected expression of the major 3.6-kb GlcNAc-6-O-sulfotransferase mRNA in all tissues tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 2 (CHST2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 2 (CHST2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 2 (CHST2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 2 (CHST2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 2 (CHST2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 2 (CHST2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 2 (CHST2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 2 (CHST2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 2 (CHST2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 2 (CHST2) ELISA Kit Customized Service Offer
  1. "Human N-acetylglucosamine-6-O-sulfotransferase involved in the biosynthesis of 6-sulfo sialyl Lewis X: molecular cloning, chromosomal mapping, and expression in various organs and tumor cells."J. Biochem. 124:670-678(1998) [PubMed] [Europe PMC] [Abstract]
  2. "CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization."Genomics 55:345-347(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Functional expression and genomic structure of human N-acetylglucosamine-6-O-sulfotransferase that transfers sulfate to b-N-acetylglucosamine at the nonreducing end of an N-acetyllactosamine sequence."Biochim. Biophys. Acta 1523:269-276(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin."J. Leukoc. Biol. 69:565-574(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization and mutagenesis of Gal/GlcNAc-6-O-sulfotransferases."Biochemistry 41:15590-15600(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression."J. Biol. Chem. 277:3979-3984(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis."J. Biol. Chem. 278:40282-40295(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Role of the carboxyl-terminal region in the activity of N-acetylglucosamine 6-o-sulfotransferase-1."J. Biochem. 136:659-664(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity."J. Biol. Chem. 279:40035-40043(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Effects of N-glycosylation on the activity and localization of GlcNAc-6-sulfotransferase 1."Glycobiology 19:1068-1077(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Expression of long-form N-acetylglucosamine-6-O-sulfotransferase 1 in human high endothelial venules."J. Histochem. Cytochem. 60:397-407(2012) [PubMed] [Europe PMC] [Abstract]