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Carbohydrate Sulfotransferase 6 (CHST6)

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MCDC1; C-GlcNAc6ST; GST4-beta; Gn6st-5; N-Acetylglucosamine 6-O Sulfotransferase 6; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta

Carbohydrate Sulfotransferase 6 (CHST6)
CCC J396
HGNC 6938
MGI 1931825
PubMed 15013869
UniProt Q9GZX3
Wiki CHST6
Hasegawa et al. (2000) determined N-acetylglucosamine-6-O-sulfotransferase (GlcNAc6ST) activity in normal corneas and corneas with keratoconus or macular corneal dystrophy by measuring the transfer of 35SO4 from (35S)3-prime phosphoadenosine 5-prime-phosphosulfate into the Gal residue of partially desulfated keratan sulfate and the nonreducing terminal GlcNAc residue of GlcNAc-beta-1/3Gal-beta-1/4GlcNAc (oligo A), respectively. GlcNAc6ST activity in the extracts from MCD-affected corneas, which was measured by using oligo A as an acceptor, was much lower than in those corneas with keratoconus and in normal control corneas. The authors concluded that the decrease in GlcNAc6ST activity in the cornea with MCD might result in the occurrence of low- or nonsulfated keratan sulfate and thereby cause corneal opacity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 6 (CHST6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 6 (CHST6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 6 (CHST6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 6 (CHST6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 6 (CHST6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 6 (CHST6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 6 (CHST6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 6 (CHST6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 6 (CHST6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 6 (CHST6) ELISA Kit Customized Service Offer
  1. "Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene."Nat. Genet. 26:237-241(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family."Glycobiology 11:75-87(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta)."Biochem. Biophys. Res. Commun. 282:928-933(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate."J. Biol. Chem. 277:42505-42513(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in corneal carbohydrate sulfotransferase 6 gene (CHST6) cause macular corneal dystrophy in Iceland."Mol. Vis. 6:261-264(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of novel mutations in the carbohydrate sulfotransferase gene (CHST6) causing macular corneal dystrophy."Invest. Ophthalmol. Vis. Sci. 43:377-382(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Truncating mutations in the carbohydrate sulfotransferase 6 gene (CHST6) result in macular corneal dystrophy."Invest. Ophthalmol. Vis. Sci. 44:2949-2953(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in the CHST6 gene in patients with macular corneal dystrophy: immunohistochemical evidence of heterogeneity."Invest. Ophthalmol. Vis. Sci. 44:3272-3277(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of novel mutations of the CHST6 gene in Vietnamese families affected with macular corneal dystrophy in two generations."Cornea 22:508-511(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Mutation analysis of the carbohydrate sulfotransferase gene in Vietnamese with macular corneal dystrophy."Invest. Ophthalmol. Vis. Sci. 44:3310-3316(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Novel mutations in the CHST6 gene associated with macular corneal dystrophy in southern India."Arch. Ophthalmol. 121:1608-1612(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Novel mutations of the carbohydrate sulfotransferase-6 (CHST6) gene causing macular corneal dystrophy in India."Mol. Vis. 9:730-734(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Novel mutations in the CHST6 gene causing macular corneal dystrophy."Clin. Genet. 65:120-125(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Novel mutations in the carbohydrate sulfotransferase gene (CHST6) in American patients with macular corneal dystrophy."Am. J. Ophthalmol. 137:465-473(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Novel CHST6 nonsense and missense mutations responsible for macular corneal dystrophy."Am. J. Ophthalmol. 139:192-193(2005) [PubMed] [Europe PMC] [Abstract]