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Capicua Homolog (CIC)

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Capicua Homolog (CIC)
CCC J404
HGNC 14214
MGI 1918972
PubMed 12393275
UniProt Q96RK0
Wiki CIC
The human cDNA predicted a 1,608-amino acid protein. Human and mouse genes exhibit 92% identity, with 100% identity in the HMG domain. Because the level of similarity of CIC to other SOX genes is insufficient for inclusion as a genuine member of the SOX subfamily, CIC represents a new member of a SOX-related HMG subfamily. RT-PCR of developing mouse central nervous system showed that Cic is highly expressed in the developing mouse brain, particularly in the immature granular cells in the cerebellum, hippocampus, and olfactory bulb.Atxn1 directly bound Cic and modulated Cic repressor activity in Drosophila and mammalian cells, and its loss decreased the steady state level of Cic. Interestingly, the S776A mutation, which abrogates the neurotoxicity of expanded Atxn1, substantially reduced the association of mutant Atxn1 with Cic in vivo.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Capicua Homolog (CIC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Capicua Homolog (CIC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Capicua Homolog (CIC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Capicua Homolog (CIC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Capicua Homolog (CIC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Capicua Homolog (CIC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Capicua Homolog (CIC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Capicua Homolog (CIC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Capicua Homolog (CIC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Capicua Homolog (CIC) ELISA Kit Customized Service Offer
  1. "CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons."Brain Res. Mol. Brain Res. 106:151-156(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
  4. "CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas."J. Neurooncol. 73:101-108(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  13. "A de novo paradigm for mental retardation."Nat. Genet. 42:1109-1112(2010) [PubMed] [Europe PMC] [Abstract]