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Collagen Type IV Alpha 3 Binding Protein (COL4a3BP)

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CERT; CERTL; GPBP; STARD11; Ceramide Transporter; StAR-Related Lipid Transfer Domain Containing 11; Goodpasture Antigen Binding Protein

Collagen Type IV Alpha 3 Binding Protein (COL4a3BP)
CCC J405
HGNC 2205
MGI 1915268
PubMed 17560332
RGD 1309131
UniProt Q9Y5P4
Wiki COL4A3BP
COL4A3BP encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Two transcripts exist for this gene.
Sequence analysis revealed that 18% of the GPBP residues are phosphorylatable and 16% are acidic. Serine residues comprise 9% of the protein, but in 2 regions account for 40% of the amino acids. There is also a pleckstrin homology domain at the N terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collagen Type IV Alpha 3 Binding Protein (COL4a3BP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collagen Type IV Alpha 3 Binding Protein (COL4a3BP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collagen Type IV Alpha 3 Binding Protein (COL4a3BP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collagen Type IV Alpha 3 Binding Protein (COL4a3BP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type IV Alpha 3 Binding Protein (COL4a3BP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collagen Type IV Alpha 3 Binding Protein (COL4a3BP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collagen Type IV Alpha 3 Binding Protein (COL4a3BP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collagen Type IV Alpha 3 Binding Protein (COL4a3BP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collagen Type IV Alpha 3 Binding Protein (COL4a3BP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type IV Alpha 3 Binding Protein (COL4a3BP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collagen Type IV Alpha 3 Binding Protein (COL4a3BP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collagen Type IV Alpha 3 Binding Protein (COL4a3BP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collagen Type IV Alpha 3 Binding Protein (COL4a3BP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collagen Type IV Alpha 3 Binding Protein (COL4a3BP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type IV Alpha 3 Binding Protein (COL4a3BP) ELISA Kit Customized Service Offer
  1. "Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen."J. Biol. Chem. 274:12642-12649(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Goodpasture antigen-binding protein, the kinase that phosphorylates the Goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis."J. Biol. Chem. 275:40392-40399(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular machinery for non-vesicular trafficking of ceramide."Nature 426:803-809(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT."J. Biol. Chem. 281:30279-30288(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein."J. Cell Biol. 178:15-22(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin."Mol. Biol. Cell 20:348-357(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide."Proc. Natl. Acad. Sci. U.S.A. 105:488-493(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer."J. Mol. Biol. 396:245-251(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]