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Calponin 2 (CNN2)

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Neutral calponin; Calponin H2, smooth muscle

Calponin 2 (CNN2)
CCC J410
HGNC 2156
MGI 105093
PubMed 23499442
UniProt Q99439
Calponin 2, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Two transcript variants encoding different isoforms have been found for this gene.
The CNN2 protein is 94.8% identical to mouse calponin h2, indicating that these proteins are homologs. The predicted CNN2 protein has 309 amino acids and a pI of 7.1. It contains motifs that are present in CNN1 and CNN3: 3 tandem repeats of 29 amino acids, an actin-binding domain, a VAV-homologous region, and 2 consensus phosphorylation sites for tyrosine kinase at the C terminus. The 3-prime untranslated region of the CNN2 mRNA contains an Alu repetitive sequence in the antisense direction.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ410Hu01 Recombinant Calponin 2 (CNN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ410Hu01 Polyclonal Antibody to Calponin 2 (CNN2) WB; IHC; ICC; IP.
MAJ410Hu21 Monoclonal Antibody to Calponin 2 (CNN2) WB
MAJ410Hu22 Monoclonal Antibody to Calponin 2 (CNN2) WB
MAJ410Hu23 Monoclonal Antibody to Calponin 2 (CNN2) WB; IHC; ICC; IP.
MAJ410Hu24 Monoclonal Antibody to Calponin 2 (CNN2) WB
MAJ410Hu25 Monoclonal Antibody to Calponin 2 (CNN2) WB; IHC; ICC; IP.
Assay Kits SEJ410Hu ELISA Kit for Calponin 2 (CNN2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calponin 2 (CNN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calponin 2 (CNN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calponin 2 (CNN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calponin 2 (CNN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calponin 2 (CNN2) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of human non-smooth muscle calponin."J. Biochem. 120:415-424(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A unique downregulation of h2-calponin gene expression in Down syndrome: a possible attenuation mechanism for fetal survival by methylation at the CpG island in the trisomic chromosome 21."Mol. Cell. Biol. 17:707-712(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of the CH domain of human calponin-2."Submitted (AUG-2005) to the PDB data bank