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Chemokine Like Receptor 1 (CMKLR1)

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ChemR23; DEZ; Chemerin Receptor 23; G-protein coupled receptor ChemR23

Chemokine Like Receptor 1 (CMKLR1)
CCC J438
HGNC 2121
MGI 109603
PubMed 22118966
RGD 69359
UniProt Q99788
Wiki CMKLR1
Chemokine receptor-like 1 is a G protein-coupled receptor for the chemoattractant adipokine chemerin and the omiga 3 fatty acid derived molecule resolvin E1.The murine receptor that shares almost 80% homology with the human receptor, is called Dez.
Activating CMKLR1 by an agonists mobilizes intracellular calcium and causes the activation of several other signaling cascades like the ERK1 and NF-κB. Initial studies of CMKLR1 suggested that it might have a role in the inflammatory pathways. Its cognate ligand, chemerin was found in joint aspirate from rheumatoid arthritis and absent in aspirate from degenerative arthritis. CMKLR1 expression by plasmacytoid dendritic cells and macrophages also helped foster this idea.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemokine Like Receptor 1 (CMKLR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemokine Like Receptor 1 (CMKLR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemokine Like Receptor 1 (CMKLR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chemokine Like Receptor 1 (CMKLR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine Like Receptor 1 (CMKLR1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemokine Like Receptor 1 (CMKLR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemokine Like Receptor 1 (CMKLR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemokine Like Receptor 1 (CMKLR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chemokine Like Receptor 1 (CMKLR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine Like Receptor 1 (CMKLR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemokine Like Receptor 1 (CMKLR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemokine Like Receptor 1 (CMKLR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemokine Like Receptor 1 (CMKLR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chemokine Like Receptor 1 (CMKLR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine Like Receptor 1 (CMKLR1) ELISA Kit Customized Service Offer
  1. "A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development."Biochem. Biophys. Res. Commun. 233:336-342(1997) [PubMed] [Europe PMC] [Abstract]
  2. "ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains."Eur. J. Immunol. 28:1689-1700(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors."Cytogenet. Cell Genet. 74:286-290(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23."FEBS Lett. 555:495-499(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids."J. Exp. Med. 198:977-985(2003) [PubMed] [Europe PMC] [Abstract]
  9. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin."J. Exp. Med. 201:509-515(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1."J. Exp. Med. 201:713-722(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands."Exp. Hematol. 34:1106-1114(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes."FEBS Lett. 582:573-578(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis."Biochem. Biophys. Res. Commun. 391:1762-1768(2010) [PubMed] [Europe PMC] [Abstract]