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Cingulin (CGN)

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Cingulin (CGN)
CCC J451
HGNC 17429
MGI 1927237
PubMed 21166484
RGD 1311992
UniProt Q9P2M7
Wiki Cingulin
Cingulin is a homodimer, each subunit containing a globular "head" domain, a long coiled-coil "rod" domain, and a small globular "tail". This domain organization is conserved throughout vertebrate species.However, cingulin homologs have not been detected in invertebrate species.
Cingulin is specifically localized at tight junctions in epithelial cells, unlike ZO-1, which is also detected at adherens-type junctions in non-epithelial cells. During early Xenopus embryo development, cingulin is detected at a cortical localization, and then accumulates at apical junctions, unlike ZO-1 and other junctional proteins, that are targeted to the new regions of cell-cell contact via the lateral domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cingulin (CGN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cingulin (CGN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cingulin (CGN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cingulin (CGN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cingulin (CGN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cingulin (CGN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cingulin (CGN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cingulin (CGN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cingulin (CGN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cingulin (CGN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cingulin (CGN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cingulin (CGN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cingulin (CGN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cingulin (CGN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cingulin (CGN) ELISA Kit Customized Service Offer
  1. "Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly."J. Struct. Biol. 131:135-145(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Evidence for a functional interaction between cingulin and ZO-1 in cultured cells."J. Biol. Chem. 277:27757-27764(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]