The corresponding antigen is designated cerebellar degeneration protein (CDR). Cloned cDNA for the protein has been isolated and characterized. The human CDR gene is in single copy and encodes a protein with a distinctive tandemly repeated structure. It is predominantly expressed in normal neuroectodermal tissues and in certain malignant tumors.
The entire hexapeptide repetitive sequence of the molecule is encoded by a single exon. Examination of corresponding mouse cDNA clones revealed similar hexapeptide repeating units and a highly conserved glu-asp core in each repetitive unit. Somatic cell hybrid analysis was used to map CDR34 to both human and mouse X chromosomes.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Cerebellar Degeneration Related Protein 1 (CDR1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Cerebellar Degeneration Related Protein 1 (CDR1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Cerebellar Degeneration Related Protein 1 (CDR1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Cerebellar Degeneration Related Protein 1 (CDR1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Cerebellar Degeneration Related Protein 1 (CDR1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Cerebellar Degeneration Related Protein 1 (CDR1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Cerebellar Degeneration Related Protein 1 (CDR1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Cerebellar Degeneration Related Protein 1 (CDR1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Cerebellar Degeneration Related Protein 1 (CDR1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Cerebellar Degeneration Related Protein 1 (CDR1) | ELISA Kit Customized Service Offer |
- "Cerebellar degeneration-related antigen: a highly conserved neuroectodermal marker mapped to chromosomes X in human and mouse."Proc. Natl. Acad. Sci. U.S.A. 87:3077-3081(1990) [PubMed] [Europe PMC] [Abstract]
- "Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration."Proc. Natl. Acad. Sci. U.S.A. 84:4552-4556(1987) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]