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Cell Division Cycle Associated Protein 5 (CDCA5)

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p35; Sororin

Cell Division Cycle Associated Protein 5 (CDCA5)
CCC J470
HGNC 14626
MGI 1915099
PubMed 20551060
RGD 1560863
UniProt Q96FF9
Wiki CDCA5
The deduced human and mouse proteins contain 252 and 264 amino acids, respectively. Both contain a KEN box for APC-dependent ubiquitination. Immunofluorescence analysis revealed a punctate nuclear distribution of CDCA5 during interphase and a diffuse distribution of CDCA5 throughout the cell during mitosis. There was no apparent concentration of CDCA5 on chromatin in mitotic cells. The level of CDCA5 dropped in synchronized HeLa cells during interphase.Overexpression of CDCA5 in Xenopus embryos caused failure to resolve and segregate sister chromatids in mitosis and increased the amount of cohesin associated with metaphase chromosomes. In cultured human and mouse cells, depletion of CDCA5 caused mitotic arrest and the complete failure of sister chromatid cohesion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Associated Protein 5 (CDCA5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Associated Protein 5 (CDCA5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Associated Protein 5 (CDCA5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Associated Protein 5 (CDCA5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Associated Protein 5 (CDCA5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Associated Protein 5 (CDCA5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Associated Protein 5 (CDCA5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Associated Protein 5 (CDCA5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Associated Protein 5 (CDCA5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Associated Protein 5 (CDCA5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Associated Protein 5 (CDCA5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Associated Protein 5 (CDCA5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Associated Protein 5 (CDCA5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Associated Protein 5 (CDCA5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Associated Protein 5 (CDCA5) ELISA Kit Customized Service Offer
  1. "Drug target discovery by gene expression analysis: cell cycle genes."Curr. Cancer Drug Targets 1:73-83(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates."Mol. Cell 18:185-200(2005) [PubMed] [Europe PMC] [Abstract]
  5. ErratumMol. Cell 18:609-609(2005)
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase."Curr. Biol. 17:630-636(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Sororin mediates sister chromatid cohesion by antagonizing wapl."Cell 143:737-749(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]