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Cell Division Cycle And Apoptosis Regulator 1 (CCAR1)

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CARP1; DIS; Cell cycle and apoptosis regulatory protein 1; Death inducer with SAP domain

Cell Division Cycle And Apoptosis Regulator 1 (CCAR1)
CCC J483
HGNC 24236
MGI 1914750
PubMed 18722177
RGD 1560358
UniProt Q8IX12
CARP1 protein contains a putative cold-shock protein domain expected to bind RNA and a putative DNA-binding motif predicted to be involved in chromosomal organization. Immunohistochemical analysis detected CARP1 in the perinuclear compartment of human breast cancer cells, and the protein had an apparent molecular mass of 130 kD by SDS-PAGE.
Increased CARP1 expression resulted in elevated levels of the cyclin-dependent kinase inhibitor p21 (CDKN1A) and apoptosis. Conversely, reduced CARP1 expression via an antisense cDNA inhibited CD437- or adriamycin- induced apoptosis. CARP1 interacted with 14-3-3 and reduced the expression of cell cycle regulatory genes, including MYC and cyclin B1 (CCNB1).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle And Apoptosis Regulator 1 (CCAR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle And Apoptosis Regulator 1 (CCAR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle And Apoptosis Regulator 1 (CCAR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle And Apoptosis Regulator 1 (CCAR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle And Apoptosis Regulator 1 (CCAR1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle And Apoptosis Regulator 1 (CCAR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle And Apoptosis Regulator 1 (CCAR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle And Apoptosis Regulator 1 (CCAR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle And Apoptosis Regulator 1 (CCAR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle And Apoptosis Regulator 1 (CCAR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle And Apoptosis Regulator 1 (CCAR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle And Apoptosis Regulator 1 (CCAR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle And Apoptosis Regulator 1 (CCAR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle And Apoptosis Regulator 1 (CCAR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle And Apoptosis Regulator 1 (CCAR1) ELISA Kit Customized Service Offer
  1. "Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437."J. Biol. Chem. 278:33422-33435(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  6. "CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes."Mol. Cell 31:510-519(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]