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Caspase 8 Associated Protein 2 (CASP8AP2)

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CED-4; FLASH; RIP25; FLICE-Associated Huge Protein

Caspase 8 Associated Protein 2 (CASP8AP2)
CCC J487
HGNC 1510
MGI 1349399
PubMed 22595458
RGD 1305771
UniProt Q9UKL3
Wiki CASP8AP2
CASP8AP2 is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.FLASH was required for 3-prime end processing of histone pre-mRNA. Truncation analysis showed that the N-terminal domain of FLASH interacted with an N-terminal domain of the U7 snRNP-specific subunit LSM11. Drosophila Flash also interacted directly with human and Drosophila LSM11.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Caspase 8 Associated Protein 2 (CASP8AP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Caspase 8 Associated Protein 2 (CASP8AP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Caspase 8 Associated Protein 2 (CASP8AP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Caspase 8 Associated Protein 2 (CASP8AP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase 8 Associated Protein 2 (CASP8AP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Caspase 8 Associated Protein 2 (CASP8AP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Caspase 8 Associated Protein 2 (CASP8AP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Caspase 8 Associated Protein 2 (CASP8AP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Caspase 8 Associated Protein 2 (CASP8AP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase 8 Associated Protein 2 (CASP8AP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ487Ra01 Recombinant Caspase 8 Associated Protein 2 (CASP8AP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ487Ra21 Monoclonal Antibody to Caspase 8 Associated Protein 2 (CASP8AP2) WB; IHC; ICC; IP.
PAJ487Ra01 Polyclonal Antibody to Caspase 8 Associated Protein 2 (CASP8AP2) WB; IHC; ICC; IP.
Assay Kits SEJ487Ra ELISA Kit for Caspase 8 Associated Protein 2 (CASP8AP2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Reply: searching for FLASH domains."Nature 401:662-663(1999)
  2. "RIP25, a human homolog of Mus musculus FLASH, is involved in IL-2 signaling."Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
  3. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract].
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] and Testis.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].
  8. "Apoptosis. Searching for FLASH domains."Nature 401:662-662(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators."J. Biol. Chem. 278:3023-3029(2003) [PubMed] [Europe PMC] [Abstract]
  10. "FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors."J. Steroid Biochem. Mol. Biol. 92:357-363(2004) [PubMed] [Europe PMC] [Abstract]
  11. "FLASH is required for histone transcription and S-phase progression."Proc. Natl. Acad. Sci. U.S.A. 103:14808-14812(2006) [PubMed] [Europe PMC] [Abstract]
  12. "FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies."EMBO J. 26:391-401(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
  14. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase."Mol. Cell. Biol. 29:4729-4741(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "PolySUMO-binding proteins identified through a string search."J. Biol. Chem. 287:42071-42083(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Solution NMR structure of CASP8-associated protein 2 from Homo sapiens, Northeast structural genomics consortium (NESG) target HR8150A."Submitted (JUN-2012) to the PDB data bank