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Calmodulin Binding Transcription Activator 1 (CAMTA1)

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Calmodulin Binding Transcription Activator 1 (CAMTA1)
CCC J500
HGNC 18806
MGI 2140230
PubMed 21857646
UniProt Q9Y6Y1
Wiki CAMTA1
By sequencing clones obtained from a size-fractionated brain cDNA library, Nagase et al. (1998) cloned CAMTA1, which they designated KIAA0833. RT-PCR ELISA detected moderate expression in adult brain and in all specific brain regions examined. Little to no expression was detected in all other tissues examined, including fetal brain.expression of CAMTA1 was highest in S and M phases and lowest in G0/G1 phase in synchronized neuroblastoma cells.
Both CAMTA1 and CAMTA2 deduced proteins contain an N-terminal DNA-binding CG1 domain, followed by a central transcription factor immunoglobulin (TIG) domain, 2 ankyrin repeats for protein-protein interactions, and 4 C-terminal calmodulin -binding IQ motifs. The CG1 domain includes a nuclear localization signal.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calmodulin Binding Transcription Activator 1 (CAMTA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calmodulin Binding Transcription Activator 1 (CAMTA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calmodulin Binding Transcription Activator 1 (CAMTA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calmodulin Binding Transcription Activator 1 (CAMTA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calmodulin Binding Transcription Activator 1 (CAMTA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calmodulin Binding Transcription Activator 1 (CAMTA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calmodulin Binding Transcription Activator 1 (CAMTA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calmodulin Binding Transcription Activator 1 (CAMTA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calmodulin Binding Transcription Activator 1 (CAMTA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calmodulin Binding Transcription Activator 1 (CAMTA1) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A novel family of calmodulin-binding transcription activators in multicellular organisms."J. Biol. Chem. 277:21851-21861(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells."Int. J. Oncol. 24:1407-1412(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene."Clin. Cancer Res. 11:1119-1128(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Intragenic CAMTA1 rearrangements cause non-progressive congenital ataxia with or without intellectual disability." J. Med. Genet. 49:400-408(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of the TIG domain of human calmodulin-binding transcription activator 1 (CAMTA1)."Submitted (DEC-2005) to the PDB data bank
  10. "Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma."Eur. J. Cancer 43:607-616(2007) [PubMed] [Europe PMC] [Abstract]