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LIM Domains Containing Protein 1 (LIMD1)

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LIM Domains Containing Protein 1 (LIMD1)
CCC J508
HGNC 6612
MGI 1352502
PubMed 22286099
RGD 1309830
UniProt Q9UGP4
Wiki LIMD1
LIM domains consist of a cysteine-rich consensus sequence containing 2 distinct zinc-binding subdomains, which mediate protein-protein interactions. The predicted protein sequences of the human and mouse genes show 3 LIM domains located at the C-terminal end, indicating that these genes belong to group 3 of the gene family encoding the LIM motifs. The predicted human LIMD1 protein contains 676 amino acids.
The LIM motif had been previously identified in many developmentally important factors from various eukaryotes. These factors had been shown to play a role in intracellular signaling, transcriptional regulation, and cellular differentiation during development. Thus, the C3CER1-located LIMD1 gene deserves further study for its possible role in tumor suppression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM Domains Containing Protein 1 (LIMD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM Domains Containing Protein 1 (LIMD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM Domains Containing Protein 1 (LIMD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM Domains Containing Protein 1 (LIMD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM Domains Containing Protein 1 (LIMD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM Domains Containing Protein 1 (LIMD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM Domains Containing Protein 1 (LIMD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM Domains Containing Protein 1 (LIMD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM Domains Containing Protein 1 (LIMD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM Domains Containing Protein 1 (LIMD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM Domains Containing Protein 1 (LIMD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM Domains Containing Protein 1 (LIMD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM Domains Containing Protein 1 (LIMD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM Domains Containing Protein 1 (LIMD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM Domains Containing Protein 1 (LIMD1) ELISA Kit Customized Service Offer
  1. "A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3."Hum. Genet. 105:552-559(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3."Genomics 73:10-19(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  5. "LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription."Proc. Natl. Acad. Sci. U.S.A. 101:16531-16536(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex."Mol. Cell. Biol. 25:4010-4022(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Cell cycle regulated phosphorylation of LIMD1 in cell lines and expression in human breast cancers."Cancer Lett. 267:55-66(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus."Dev. Cell 14:424-436(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival."Int. J. Cancer 123:2247-2253(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Ajuba LIM proteins are negative regulators of the Hippo signaling pathway."Curr. Biol. 20:657-662(2010) [PubMed] [Europe PMC] [Abstract]
  14. "LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing."Proc. Natl. Acad. Sci. U.S.A. 107:12499-12504(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity."Nat. Cell Biol. 14:201-208(2012) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]