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LIM Domain Kinase 1 (LIMK1)

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LIM Domain Kinase 1 (LIMK1)
CCC J509
HGNC 6613
MGI 104572
PubMed 23362664
RGD 62055
UniProt P53667
Wiki LIMK1
LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM Domain Kinase 1 (LIMK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM Domain Kinase 1 (LIMK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM Domain Kinase 1 (LIMK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM Domain Kinase 1 (LIMK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM Domain Kinase 1 (LIMK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM Domain Kinase 1 (LIMK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM Domain Kinase 1 (LIMK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM Domain Kinase 1 (LIMK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM Domain Kinase 1 (LIMK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM Domain Kinase 1 (LIMK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM Domain Kinase 1 (LIMK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM Domain Kinase 1 (LIMK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM Domain Kinase 1 (LIMK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM Domain Kinase 1 (LIMK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM Domain Kinase 1 (LIMK1) ELISA Kit Customized Service Offer
  1. "Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif."Oncogene 9:1605-1612(1994) [PubMed] [Europe PMC] [Abstract]
  2. "LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition."Cell 86:59-69(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients."Genomics 36:328-336(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Structural features of LIM kinase that control effects on the actin cytoskeleton."J. Biol. Chem. 274:11352-11361(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics."Nat. Cell Biol. 1:253-259(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase."Science 285:895-898(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop."J. Biol. Chem. 275:3577-3582(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha."J. Biol. Chem. 276:23092-23096(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin."J. Biol. Chem. 276:32115-32121(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin."Cell 108:233-246(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells."J. Biol. Chem. 278:33450-33455(2003) [PubMed] [Europe PMC] [Abstract]
  14. "p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus."J. Biol. Chem. 278:52919-52923(2003) [PubMed] [Europe PMC] [Abstract]
  15. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin."EMBO J. 24:473-486(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration."J. Cell Biol. 171:349-359(2005) [PubMed] [Europe PMC] [Abstract]
  18. "MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration."EMBO J. 25:713-726(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Hsp90 increases LIM kinase activity by promoting its homo-dimerization."FASEB J. 20:1218-1220(2006) [PubMed] [Europe PMC] [Abstract]
  20. "The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules."Exp. Cell Res. 313:4091-4106(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Lim kinases, regulators of actin dynamics."Int. J. Biochem. Cell Biol. 39:1071-1076(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  23. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  26. "LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators."Med. Res. Rev. 32:968-998(2012) [PubMed] [Europe PMC] [Abstract]
  27. "Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression."Mol. Cancer 10:75-75(2011) [PubMed] [Europe PMC] [Abstract]
  28. "Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6."Sci. Signal. 6:RA30-RA30(2013) [PubMed] [Europe PMC] [Abstract]
  29. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  30. "Crystal structure of the human limk1 kinase domain in complex with staurosporine."Submitted (JUL-2011) to the PDB data bank