Large Tumor Suppressor Homolog 2 (LATS2)
[Edit]KPM; Kinase phosphorylated during mitosis protein; Serine/threonine-protein kinase kpm; Warts-like kinase; Serine/threonine-protein kinase LATS2
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LATS2 encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis.
It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Large Tumor Suppressor Homolog 2 (LATS2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Large Tumor Suppressor Homolog 2 (LATS2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Large Tumor Suppressor Homolog 2 (LATS2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Large Tumor Suppressor Homolog 2 (LATS2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Large Tumor Suppressor Homolog 2 (LATS2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Large Tumor Suppressor Homolog 2 (LATS2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Large Tumor Suppressor Homolog 2 (LATS2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Large Tumor Suppressor Homolog 2 (LATS2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Large Tumor Suppressor Homolog 2 (LATS2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Large Tumor Suppressor Homolog 2 (LATS2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Large Tumor Suppressor Homolog 2 (LATS2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Large Tumor Suppressor Homolog 2 (LATS2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Large Tumor Suppressor Homolog 2 (LATS2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Large Tumor Suppressor Homolog 2 (LATS2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Large Tumor Suppressor Homolog 2 (LATS2) | ELISA Kit Customized Service Offer |
- "Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor."Oncogene 19:3101-3109(2000) [PubMed] [Europe PMC] [Abstract].
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
- "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts."Genomics 63:263-270(2000) [PubMed] [Europe PMC] [Abstract]
- Ref.5"Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts."Genomics 63:263-270(2000) [PubMed] [Europe PMC] [Abstract]
- "Lats2, a putative tumor suppressor, inhibits G1/S transition."Oncogene 22:4398-4405(2003) [PubMed] [Europe PMC] [Abstract]
- "The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase."Genes Cells 9:383-397(2004) [PubMed] [Europe PMC] [Abstract]
- "The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor."Mol. Endocrinol. 18:2011-2023(2004) [PubMed] [Europe PMC] [Abstract]
- "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1."Oncogene 24:2076-2086(2005) [PubMed] [Europe PMC] [Abstract]
- "LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis."FEBS Lett. 580:782-788(2006) [PubMed] [Europe PMC] [Abstract]
- "Tumor suppressor LATS1 is a negative regulator of oncogene YAP."J. Biol. Chem. 283:5496-5509(2008) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Ajuba LIM proteins are negative regulators of the Hippo signaling pathway."Curr. Biol. 20:657-662(2010) [PubMed] [Europe PMC] [Abstract]
- "Molecular characterization of human homologs of yeast MOB1."Int. J. Cancer 126:2079-2089(2010) [PubMed] [Europe PMC] [Abstract]
- "Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation."EMBO J. 31:29-43(2012) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]