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Lysocardiolipin Acyltransferase 1 (LCLAT1)

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LYCAT; ALCAT1; AGPAT8; 1-acylglycerol-3-phosphate O-acyltransferase 8; Acyl-CoA:lysocardiolipin acyltransferase 1

Lysocardiolipin Acyltransferase 1 (LCLAT1)
CCC J517
HGNC 26756
MGI 2684937
RGD 1565906
UniProt Q6UWP7
AGPAT1 is also called LPAATα, and AGPAT8 is also known as AGPAT9, LPAATθ, or GPAT3. Confusingly, LCLAT1 was also given the name AGPAT8. Human LPGAT1 overexpressed in COS-7 cells showed a clear preference for 16:0-, 18:0-, and 18:1-CoAs as donors, which is consistent with the composition of endogenous PG in several tissues. Human LPGAT1 is widely distributed in tissues. The enzyme has the KKXX motif and is localized to the ER.
Mouse LCLAT1 is widely distributed, with the highest expression seen in the heart and liver. When LCLAT1 was overexpressed in COS-7 cells, the enzyme localized to the ER. The subcellular localization was predicted by the existence of a KKXX motif, an ER retention signal at the C-terminal end of LCLAT1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lysocardiolipin Acyltransferase 1 (LCLAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lysocardiolipin Acyltransferase 1 (LCLAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysocardiolipin Acyltransferase 1 (LCLAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lysocardiolipin Acyltransferase 1 (LCLAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lysocardiolipin Acyltransferase 1 (LCLAT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lysocardiolipin Acyltransferase 1 (LCLAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lysocardiolipin Acyltransferase 1 (LCLAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysocardiolipin Acyltransferase 1 (LCLAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lysocardiolipin Acyltransferase 1 (LCLAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lysocardiolipin Acyltransferase 1 (LCLAT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lysocardiolipin Acyltransferase 1 (LCLAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lysocardiolipin Acyltransferase 1 (LCLAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysocardiolipin Acyltransferase 1 (LCLAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lysocardiolipin Acyltransferase 1 (LCLAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lysocardiolipin Acyltransferase 1 (LCLAT1) ELISA Kit Customized Service Offer
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  5. "Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity."Arch. Biochem. Biophys. 449:64-76(2006) [PubMed] [Europe PMC] [Abstract]
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