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Leucine Rich, Glioma Inactivated 1 (LGI1)

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EPT; ETL1; Epitempin-1; Epilepsy; Partial

Leucine Rich, Glioma Inactivated 1 (LGI1)
CCC J525
HGNC 6572
MGI 1861691
PubMed 24227725
RGD 628742
UniProt O95970
Wiki LGI1
LGI1contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas.LGI1 gene has been implicated in the control of cancer metastasis and in a predisposition to epilepsy. Following genetic linkage studies placing the hereditary form of autosomal dominant partial epilepsy with Auditory features (ADPEAF) on chromosome region 10q24 mutation analysis of affected members in these families demonstrated LGI1 was the cause of the disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich, Glioma Inactivated 1 (LGI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich, Glioma Inactivated 1 (LGI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich, Glioma Inactivated 1 (LGI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich, Glioma Inactivated 1 (LGI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich, Glioma Inactivated 1 (LGI1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich, Glioma Inactivated 1 (LGI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich, Glioma Inactivated 1 (LGI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich, Glioma Inactivated 1 (LGI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich, Glioma Inactivated 1 (LGI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich, Glioma Inactivated 1 (LGI1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich, Glioma Inactivated 1 (LGI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich, Glioma Inactivated 1 (LGI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich, Glioma Inactivated 1 (LGI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich, Glioma Inactivated 1 (LGI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich, Glioma Inactivated 1 (LGI1) ELISA Kit Customized Service Offer
  1. "A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors."Oncogene 17:2873-2881(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy." Hum. Mol. Genet. 11:1119-1128(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway."J. Biol. Chem. 279:23151-23157(2004) [PubMed] [Europe PMC] [Abstract]
  8. ErratumJ. Biol. Chem. 282:2752-2752(2007)
  9. "The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface."Hum. Mol. Genet. 15:3436-3445(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Increased expression of LGI1 gene triggers growth inhibition and apoptosis of neuroblastoma cells."J. Cell. Physiol. 207:711-721(2006) [PubMed] [Europe PMC] [Abstract]
  11. "The LGI1/epitempin gene encodes two protein isoforms differentially expressed in human brain."J. Neurochem. 98:985-991(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Two novel epilepsy-linked mutations leading to a loss of function of LGI1."Arch. Neurol. 64:217-222(2007) [PubMed] [Europe PMC] [Abstract]
  13. "LGI1 mutations in autosomal dominant and sporadic lateral temporal epilepsy."Hum. Mutat. 30:530-536(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features."Nat. Genet. 30:335-341(2002) [PubMed] [Europe PMC] [Abstract]
  15. "LGI1 is mutated in familial temporal lobe epilepsy characterized by aphasic seizures."Ann. Neurol. 52:364-367(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Epilepsy with auditory features: a LGI1 gene mutation suggests a loss-of-function mechanism."Ann. Neurol. 53:396-399(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Novel LGI1 mutation in a family with autosomal dominant partial epilepsy with auditory features."Neurology 60:1687-1690(2003) [PubMed] [Europe PMC] [Abstract]
  18. "LGI1 mutations in temporal lobe epilepsies."Neurology 62:1115-1119(2004) [PubMed] [Europe PMC] [Abstract]
  19. "A de novo LGI1 mutation causing idiopathic partial epilepsy with telephone-induced seizures."Neurology 68:2150-2151(2007) [PubMed] [Europe PMC] [Abstract]
  20. "A novel loss-of-function LGI1 mutation linked to autosomal dominant lateral temporal epilepsy."Arch. Neurol. 65:939-942(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Drug resistant ADLTE and recurrent partial status epilepticus with dysphasic features in a family with a novel LGI1mutation: electroclinical, genetic, and EEG/fMRI findings."Epilepsia 50:2481-2486(2009) [PubMed] [Europe PMC] [Abstract]