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Brain Selective Kinase 2 (BRSK2)

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STK29; C11orf7; PEN11B; SADA; PEN11B; HUSSY-12; BR Serine/Threonine Kinase 2; Serine/Threonine Kinase 29; Brain-specific serine/threonine-protein kinase 2

Brain Selective Kinase 2 (BRSK2)
CCC J530
HGNC 11405
MGI 1923020
PubMed 22798068
RGD 1566256
UniProt Q8IWQ3
Wiki BRSK2
The deduced protein contains 149 amino acids. Northern blot analysis detected a major 3.8-kb transcript and a minor 4.2-kb transcript expressed mainly in brain and pancreas, with weaker expression in testis. Expression was not detected in other tissues examined. BRSK2 was preferentially expressed from the maternal allele in placenta, but no allelic preference was detected in brain, liver, and kidney. They concluded that BRSK2 is an atypical imprinted gene.
The deduced 778-amino acid protein has a calculated molecular mass of 87 kD. Phylogenetic analysis indicated that BRSK2 belongs to the MARK subfamily of kinases. Northern blot analysis detected ubiquitous expression of a 3.5-kb transcript, with highest levels in brain and testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Brain Selective Kinase 2 (BRSK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Brain Selective Kinase 2 (BRSK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Brain Selective Kinase 2 (BRSK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Brain Selective Kinase 2 (BRSK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Brain Selective Kinase 2 (BRSK2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Brain Selective Kinase 2 (BRSK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Brain Selective Kinase 2 (BRSK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Brain Selective Kinase 2 (BRSK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Brain Selective Kinase 2 (BRSK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Brain Selective Kinase 2 (BRSK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Brain Selective Kinase 2 (BRSK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Brain Selective Kinase 2 (BRSK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Brain Selective Kinase 2 (BRSK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Brain Selective Kinase 2 (BRSK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Brain Selective Kinase 2 (BRSK2) ELISA Kit Customized Service Offer
  1. "SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release."Neuron 50:261-275(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of 16 novel human genes showing high similarity to yeast sequences."Yeast 18:69-80(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta."J. Hum. Genet. 44:1-9(1999) [PubMed] [Europe PMC] [Abstract]
  7. "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1."EMBO J. 23:833-843(2004) [PubMed] [Europe PMC] [Abstract]
  8. "BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260."Biochem. Biophys. Res. Commun. 347:867-871(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation."J. Biol. Chem. 283:14946-14954(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP."Biochem. J. 426:109-118(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity."J. Cell Sci. 123:286-294(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway."Biochem. Biophys. Res. Commun. 422:647-652(2012) [PubMed] [Europe PMC] [Abstract]
  16. "BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis."Biochem. Biophys. Res. Commun. 423:813-818(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic beta-Cells."J. Biol. Chem. 287:26435-26444(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells."J. Biol. Chem. 287:30368-30375(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Phosphorylation of microtubule-associated protein tau by AMPK-related kinases."J. Neurochem. 120:165-176(2012) [PubMed] [Europe PMC] [Abstract]
  20. "APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway."PLoS ONE 7:E45932-E45932(2012) [PubMed] [Europe PMC] [Abstract]