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Brain And Reproductive Organ Expressed Protein (BRE)

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BRCC4; BRCC45; BRCA1/BRCA2-Containing Complex,Subunit 4; BRCA1-A complex subunit BRE

Brain And Reproductive Organ Expressed Protein (BRE)
CCC J531
HGNC 1106
MGI 1333875
PubMed 9737713
RGD 735111
UniProt Q9NXR7
Wiki BRE
The expression of BRE decreased following DNA damage in normal human fibroblasts caused by UV irradiation or 4-nitroquinoline-1-oxide (4NQO) exposure. Similar decreased BRE expression was observed in retinoic acid-treated human brain glioma cells and promyelocytic cells. BRE expression was unchanged in cells following growth inhibition.
The deduced protein contains 383 amino acids. Northern blot analysis of normal human fibroblasts detected a single BRE mRNA at 1.7 to 1.9 kb. Northern blot analysis of several rat tissues detected highest expression in testis and intermediate expression in brain and ovary.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Brain And Reproductive Organ Expressed Protein (BRE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Brain And Reproductive Organ Expressed Protein (BRE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Brain And Reproductive Organ Expressed Protein (BRE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Brain And Reproductive Organ Expressed Protein (BRE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Brain And Reproductive Organ Expressed Protein (BRE) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Brain And Reproductive Organ Expressed Protein (BRE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Brain And Reproductive Organ Expressed Protein (BRE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Brain And Reproductive Organ Expressed Protein (BRE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Brain And Reproductive Organ Expressed Protein (BRE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Brain And Reproductive Organ Expressed Protein (BRE) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Brain And Reproductive Organ Expressed Protein (BRE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Brain And Reproductive Organ Expressed Protein (BRE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Brain And Reproductive Organ Expressed Protein (BRE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Brain And Reproductive Organ Expressed Protein (BRE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Brain And Reproductive Organ Expressed Protein (BRE) ELISA Kit Customized Service Offer
  1. "Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid."Biochem. Biophys. Res. Commun. 206:764-774(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of human BRE in multiple isoforms."Biochem. Biophys. Res. Commun. 288:535-545(2001) [PubMed] [Europe PMC] [Abstract] and Teratocarcinoma.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  5. "A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway."J. Biol. Chem. 279:52106-52116(2004) [PubMed] [Europe PMC] [Abstract]
  6. "RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites."Science 316:1198-1202(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1."EMBO J. 28:621-631(2009) [PubMed] [Europe PMC] [Abstract]
  9. "MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks."Genes Dev. 23:740-754(2009) [PubMed] [Europe PMC] [Abstract]
  10. "NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control."Genes Dev. 23:729-739(2009) [PubMed] [Europe PMC] [Abstract]
  11. "MERIT40 facilitates BRCA1 localization and DNA damage repair."Genes Dev. 23:719-728(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]