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Glutathione S Transferase Zeta 1 (GSTz1)

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MAAI; MAI; Maleylacetoacetate Isomerase

Glutathione S Transferase Zeta 1 (GSTz1)
CCC J538
HGNC 4643
MGI 1341859
PubMed 21303221
RGD 1589363
UniProt O43708
Wiki GSTZ1
GSTZ1 is a member of the GSTs super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms.Human GSTZ1-1 was 38% and 49% identical to the carnation and C. elegans proteins, respectively. The authors found that recombinant human GSTZ1-1 was a dimer composed of 24.2-kD subunits. GSTZ1-1 was most abundant in liver, with lower levels detected in skeletal muscle and brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutathione S Transferase Zeta 1 (GSTz1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glutathione S Transferase Zeta 1 (GSTz1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutathione S Transferase Zeta 1 (GSTz1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glutathione S Transferase Zeta 1 (GSTz1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutathione S Transferase Zeta 1 (GSTz1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutathione S Transferase Zeta 1 (GSTz1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glutathione S Transferase Zeta 1 (GSTz1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutathione S Transferase Zeta 1 (GSTz1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glutathione S Transferase Zeta 1 (GSTz1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutathione S Transferase Zeta 1 (GSTz1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutathione S Transferase Zeta 1 (GSTz1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glutathione S Transferase Zeta 1 (GSTz1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutathione S Transferase Zeta 1 (GSTz1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glutathione S Transferase Zeta 1 (GSTz1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutathione S Transferase Zeta 1 (GSTz1) ELISA Kit Customized Service Offer
  1. "Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue."J. Biol. Chem. 273:329-337(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Zeta, a novel class of glutathione transferases in a range of species from plants to humans."Biochem. J. 328:929-935(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization and chromosome location of the gene GSTZ1 encoding the human zeta class glutathione transferase and maleylacetoacetate isomerase."Cytogenet. Cell Genet. 83:109-114(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase."Genomics 58:263-269(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid."Biochem. J. 331:371-374(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis."Pharmacogenetics 10:49-57(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity."Biochemistry 40:1567-1576(2001) [PubMed] [Europe PMC] [Abstract]