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Polyhomeotic Like Protein 2 (PHC2)

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EDR2; HPH2; PH2; Early Development Regulator 2; Polyhomeotic-Like 2

Polyhomeotic Like Protein 2 (PHC2)
CCC J542
HGNC 3183
MGI 1860454
PubMed 16024804
RGD 1307912
UniProt Q8IXK0
Wiki PHC2
In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex.
PHC2 has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.The authors concluded that HPH1, HPH2, and BMI1 are part of a common, multimeric protein complex. Northern blot analysis revealed that HPH2 was expressed ubiquitously as a 2.5-kb transcript.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polyhomeotic Like Protein 2 (PHC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polyhomeotic Like Protein 2 (PHC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polyhomeotic Like Protein 2 (PHC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polyhomeotic Like Protein 2 (PHC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polyhomeotic Like Protein 2 (PHC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polyhomeotic Like Protein 2 (PHC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polyhomeotic Like Protein 2 (PHC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polyhomeotic Like Protein 2 (PHC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polyhomeotic Like Protein 2 (PHC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polyhomeotic Like Protein 2 (PHC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polyhomeotic Like Protein 2 (PHC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polyhomeotic Like Protein 2 (PHC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polyhomeotic Like Protein 2 (PHC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polyhomeotic Like Protein 2 (PHC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polyhomeotic Like Protein 2 (PHC2) ELISA Kit Customized Service Offer
  1. "Identification and characterisation of novel mammalian homologues of Drosophila polyhomeotic permits new insights into relationships between members of the polyhomeotic family."Hum. Genet. 111:435-442(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening."Mol. Cell. Biochem. 210:131-142(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic."Mol. Cell. Biol. 17:2326-2335(1997) [PubMed] [Europe PMC] [Abstract]
  7. "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor."Mol. Cell. Biol. 17:4105-4113(1997) [PubMed] [Europe PMC] [Abstract]
  8. "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans."Mol. Cell. Biol. 22:6070-6078(2002) [PubMed] [Europe PMC] [Abstract]
  9. "P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity."FEBS Lett. 564:205-211(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Role of histone H2A ubiquitination in Polycomb silencing."Nature 431:873-878(2004) [PubMed] [Europe PMC] [Abstract]
  11. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus."PLoS ONE 4:E6380-E6380(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]