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Biliverdin Reductase B (BLVRB)

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FLR; SDR43U1; Flavin Reductase,NADPH; Short Chain Dehydrogenase/Reductase Family 43U,Member 1; Biliverdin-IX beta-reductase; Green heme-binding protein

Biliverdin Reductase B (BLVRB)
CCC J550
HGNC 1063
MGI 2385271
PubMed 21478226
RGD 1306080
UniProt P30043
The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B. BLVRB is found predominantly in fetal liver. BLVRA is a major component of human adult liver and is identical to the enzyme previously reported as biliverdin reductase.
The FLR cDNA, which appeared to be identical to the BLVRB cDNA, encodes a deduced 206-amino acid protein. Western blot analysis of rat tissues showed highest levels of FLR in the erythrocytes and liver. Northern blot analysis detected a 1.1-kb transcript in human tissues. that flavins are the effective electron acceptor of the enzyme and purified FLR to homogeneity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ550Hu01 Recombinant Biliverdin Reductase B (BLVRB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ550Hu21 Monoclonal Antibody to Biliverdin Reductase B (BLVRB) WB; IHC; ICC; IP.
PAJ550Hu01 Polyclonal Antibody to Biliverdin Reductase B (BLVRB) WB; IHC; ICC/IF
Assay Kits SEJ550Hu ELISA Kit for Biliverdin Reductase B (BLVRB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Biliverdin Reductase B (BLVRB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Biliverdin Reductase B (BLVRB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Biliverdin Reductase B (BLVRB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Biliverdin Reductase B (BLVRB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Biliverdin Reductase B (BLVRB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Biliverdin Reductase B (BLVRB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Biliverdin Reductase B (BLVRB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Biliverdin Reductase B (BLVRB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Biliverdin Reductase B (BLVRB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Biliverdin Reductase B (BLVRB) ELISA Kit Customized Service Offer
  1. "Cloning and nucleotide sequence of a cDNA of the human erythrocyte NADPH-flavin reductase."Biochem. Biophys. Res. Commun. 198:1170-1176(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and expression of human liver biliverdin-IXbeta reductase."Biol. Pharm. Bull. 19:796-804(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Complete amino acid sequence of biliverdin-IX beta reductase from human liver."Biochem. Biophys. Res. Commun. 197:1518-1523(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization."J. Biol. Chem. 269:24343-24348(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Human liver protein map: a reference database established by microsequencing and gel comparison."Electrophoresis 13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Plasma and red blood cell protein maps: update 1993."Electrophoresis 14:1223-1231(1993) [PubMed] [Europe PMC] [Abstract]
  10. , Submitted (DEC-2008) to UniProtKB
  11. "Evidence that biliverdin-IX beta reductase and flavin reductase are identical."Biochem. J. 316:385-387(1996) [PubMed] [Europe PMC] [Abstract]
  12. "Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B)."Biochem. J. 345:393-399(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Computational and experimental studies on the catalytic mechanism of biliverdin-IXbeta reductase."Biochem. J. 411:475-484(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme."Nat. Struct. Biol. 8:215-220(2001) [PubMed] [Europe PMC] [Abstract]