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Biliverdin Reductase A (BLVRA)

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BLVR; BVR; Biliverdin-IX alpha-reductase

Biliverdin Reductase A (BLVRA)
CCC J551
HGNC 1062
MGI 88170
PubMed 23536765
RGD 620721
UniProt P53004
Biliverdin reductases, such as BLVRA (EC 1.3.1.24), catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH.
The deduced 296-amino acid protein has a calculated molecular mass of 33.2 kD. Removal of 2 N-terminal amino acids results in a 294-amino acid mature protein with an N-terminal threonine. The N-terminal region contains the NADH/NADPH-binding consensus sequence. BLVRA shares 82.8% amino acid identity with rat Blvra, but it does not share significant homology with BLVRB. Northern blot analysis detected BLVRA at 1.35 kb in all 8 tissues examined. Expression was highest in brain, pancreas, and lung, and lowest in liver and placenta.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ551Hu01 Recombinant Biliverdin Reductase A (BLVRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ551Hu21 Monoclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IP.
PAJ551Hu01 Polyclonal Antibody to Biliverdin Reductase A (BLVRA) WB,IHC
Assay Kits SEJ551Hu ELISA Kit for Biliverdin Reductase A (BLVRA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Biliverdin Reductase A (BLVRA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Biliverdin Reductase A (BLVRA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Biliverdin Reductase A (BLVRA) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ551Mu ELISA Kit for Biliverdin Reductase A (BLVRA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ551Ra01 Recombinant Biliverdin Reductase A (BLVRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ551Ra21 Monoclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IP.
PAJ551Ra01 Polyclonal Antibody to Biliverdin Reductase A (BLVRA) WB,IHC
Assay Kits SEJ551Ra ELISA Kit for Biliverdin Reductase A (BLVRA) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Human biliverdin IXalpha reductase is a zinc-metalloprotein. Characterization of purified and Escherichia coli expressed enzymes."Eur. J. Biochem. 235:372-381(1996) [PubMed] [Europe PMC] [Abstract]
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  10. "A novel mutation in the biliverdin reductase-A gene combined with liver cirrhosis results in hyperbiliverdinaemia (green jaundice)."Liver Int. 29:1116-1124(2009) [PubMed] [Europe PMC] [Abstract]
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  15. "Crystal structure of human biliverdin reductase A."Submitted (FEB-2009) to the PDB data bank