Anterior Gradient Protein 3 (AGR3)
[Edit]BCMP11; HAG3; hAG-3; PDIA18; Breast Cancer Membrane Protein 11; Protein Disulfide Isomerase Family A,Member 18
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Fluorescence-tagged BCMP11 localized in secretory or endosome-like organelles in transfected breast carcinoma cell lines. Immunohistochemical analysis showed that expression of BCMP11 was restricted in normal tissues, with significant staining of only the epithelial lining of colonic mucosa. However, BCMP11 was detected in 43 of 58 (74%) breast cancer tissues tested, but not in normal breast ductal epithelial cells. In cancerous epithelial cells, BCMP11 localized to the cytoplasm.Expression of AG2 and AG3 showed a positive correlation with expression of estrogen receptor and a negative correlation with expression of EGF receptor (EGFR). Yeast 2-hybrid analysis identified C4.4A and extracellular alpha-dystroglycan (DAG1) as binding partners for both AG2 and AG3.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Anterior Gradient Protein 3 (AGR3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Anterior Gradient Protein 3 (AGR3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Anterior Gradient Protein 3 (AGR3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Anterior Gradient Protein 3 (AGR3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Anterior Gradient Protein 3 (AGR3) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Anterior Gradient Protein 3 (AGR3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Anterior Gradient Protein 3 (AGR3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Anterior Gradient Protein 3 (AGR3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Anterior Gradient Protein 3 (AGR3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Anterior Gradient Protein 3 (AGR3) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Anterior Gradient Protein 3 (AGR3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Anterior Gradient Protein 3 (AGR3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Anterior Gradient Protein 3 (AGR3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Anterior Gradient Protein 3 (AGR3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Anterior Gradient Protein 3 (AGR3) | ELISA Kit Customized Service Offer |
- "Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer."J. Biol. Chem. 278:6482-6489(2003) [PubMed] [Europe PMC] [Abstract]
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
- "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
- "hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan."Br. J. Cancer 88:579-585(2003) [PubMed] [Europe PMC] [Abstract]