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Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK)

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BCKDHKIN; 3-Methyl-2-Oxobutanoate Dehydrogenase/Lipoamide Kinase,Mitochondrial

Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK)
CCC J560
HGNC 16902
MGI 1276121
PubMed 24449431
RGD 2198
UniProt O14874
Wiki BCKDK
Muscle biopsies from the vastus lateralis were obtained before and after 90 min of cycling at 65% VO2max in 12 women and 12 men. The women performed the exercise bout during the follicular (FOL, day 7–9) and luteal (LUT, day 19–21) phases. The men performed the exercise bout after eight days of ES (2 mg/d) and placebo (PL) supplementation, following a randomized, double-blind, cross-over design. Menstrual phase and ES had no influence on the mRNA content of AST, BCKD and BCKDK. Inactivating mutations in the BCKDK gene, which codes for the kinase responsible for the negative regulation of the branched-chain α-keto acid dehydrogenase complex (BCKD), have recently been associated with a form of autism in three families.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ560Ra01 Recombinant Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ560Ra01 Polyclonal Antibody to Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) WB; IHC; ICC; IP.
MAJ560Ra21 Monoclonal Antibody to Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) WB; IHC; ICC; IP.
Assay Kits SEJ560Ra ELISA Kit for Branched Chain Alpha-Ketoacid Dehydrogenase Kinase (BCKDK) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy." Science 338:394-397(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Two novel mutations in the BCKDK (branched-chain keto-acid dehydrogenase kinase) gene are responsible for a neurobehavioral deficit in two pediatric unrelated patients." Hum. Mutat. 35:470-477(2014) [PubMed] [Europe PMC] [Abstract]