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B-Cell Receptor Associated Protein 31 (BCAP31)

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CDM; 6C6-AG; BAP31; p28; Protein CDM; 6C6-AG tumor-associated antigen

B-Cell Receptor Associated Protein 31 (BCAP31)
CCC J561
HGNC 16695
MGI 1350933
PubMed 24011989
RGD 1302944
UniProt P51572
Wiki BCAP31
BCAP31 encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in the caspase 8-mediated apoptosis.
Microdeletions in this gene are associated with the contiguous ABCD1/DXS1375E deletion syndrome. Two pseudogenes have been identified on chromosome 16. Alternatively spliced transcript variants encoding distinct isoforms have been described although the biological validity of some of the variants has not been determined.Patients manifest profound neonatal hypotonia, subsequent failure to thrive, and cholestatic liver disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell Receptor Associated Protein 31 (BCAP31) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell Receptor Associated Protein 31 (BCAP31) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell Receptor Associated Protein 31 (BCAP31) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell Receptor Associated Protein 31 (BCAP31) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell Receptor Associated Protein 31 (BCAP31) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell Receptor Associated Protein 31 (BCAP31) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell Receptor Associated Protein 31 (BCAP31) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell Receptor Associated Protein 31 (BCAP31) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell Receptor Associated Protein 31 (BCAP31) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell Receptor Associated Protein 31 (BCAP31) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell Receptor Associated Protein 31 (BCAP31) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell Receptor Associated Protein 31 (BCAP31) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell Receptor Associated Protein 31 (BCAP31) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell Receptor Associated Protein 31 (BCAP31) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell Receptor Associated Protein 31 (BCAP31) ELISA Kit Customized Service Offer
  1. "A new human gene (DXS1357E) with ubiquitous expression, located in Xq28 adjacent to the adrenoleukodystrophy gene."Genomics 22:469-471(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of a transmembrane surface antigen in human cells."Eur. J. Biochem. 238:631-638(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence."EMBO J. 15:1534-1541(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum."J. Cell Biol. 139:327-338(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31."J. Cell Biol. 139:1397-1410(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Caspase-resistant BAP31 inhibits Fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria."Mol. Cell. Biol. 20:6731-6740(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Proteomics characterization of abundant Golgi membrane proteins."J. Biol. Chem. 276:5152-5165(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Endoplasmic reticulum membrane-sorting protein of lymphocytes (BAP31) is highly expressed in neurons and discrete endocrine cells."J. Histochem. Cytochem. 49:1235-1243(2001) [PubMed] [Europe PMC] [Abstract]
  12. "The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum."Proc. Natl. Acad. Sci. U.S.A. 99:4331-4336(2002) [PubMed] [Europe PMC] [Abstract]
  13. "The yeast split-ubiquitin membrane protein two-hybrid screen identifies BAP31 as a regulator of the turnover of endoplasmic reticulum-associated protein tyrosine phosphatase-like B."Mol. Cell. Biol. 24:2767-2778(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Contiguous deletion of the X-linked adrenoleukodystrophy gene (ABCD1) and DXS1357E: a novel neonatal phenotype similar to peroxisomal biogenesis disorders."Am. J. Hum. Genet. 70:1520-1531(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Bap31 is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER-associated Degradation."Mol. Biol. Cell 19:1825-1836(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Mutations in BCAP31 cause a severe X-linked phenotype with deafness, dystonia, and central hypomyelination and disorganize the Golgi apparatus."Am. J. Hum. Genet. 93:579-586(2013) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Structural and biophysical characterization of the cytoplasmic domains of human BAP29 and BAP31."PLoS ONE 8:E71111-E71111(2013) [PubMed] [Europe PMC] [Abstract]