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Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF)

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B-ATF; BATF1; SFA-2; Activating Transcription Factor B; SF-HT-Activated Gene 2; B-cell-activating transcription factor

Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF)
CCC J562
HGNC 958
MGI 1859147
PubMed 21873234
RGD 1304923
UniProt Q16520
Wiki BATF
BATF is a nuclear basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.Mice without the BATF gene lacked a type of inflammatory immune cell (Th17) and were resistant to conditions that normally induces an autoimmune condition similar to multiple sclerosis.
Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Basic Leucine Zipper Transcription Factor, ATF Like Protein (BATF) ELISA Kit Customized Service Offer
  1. "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family."Oncogene 11:2255-2265(1995) [PubMed] [Europe PMC] [Abstract]
  2. "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes."Biochem. Biophys. Res. Commun. 222:164-170(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization of human B-ATF, a target for regulation by EBV and HTLV-1."Mamm. Genome 9:849-852(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors."Biochem. Biophys. Res. Commun. 229:316-322(1996) [PubMed] [Europe PMC] [Abstract]
  7. "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos."Oncogene 19:1752-1763(2000) [PubMed] [Europe PMC] [Abstract]
  8. "EBNA2 and activated Notch induce expression of BATF."J. Virol. 77:6029-6040(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF." Nat. Med. 16:1147-1151(2010) [PubMed] [Europe PMC] [Abstract]