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BRCA1 Associated Protein 1 (BAP1)

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HUCEP-13; Hucep-6; UCHL2; Ubiquitin Carboxy-Terminal Hydrolase; Cerebral protein 6

BRCA1 Associated Protein 1 (BAP1)
CCC J565
HGNC 950
MGI 1206586
PubMed 23550303
RGD 1311938
UniProt Q92560
Wiki BAP1
BAP1 encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.
The N-terminal 240 amino acids of the predicted 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases , thiol proteases that catalyze proteolytic processing of ubiquitin. In addition, BAP1 contains an acidic region, a highly charged C-terminal region, and 2 putative nuclear localization signals. Recombinant BAP1 had UCH activity in vitro.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BRCA1 Associated Protein 1 (BAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BRCA1 Associated Protein 1 (BAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BRCA1 Associated Protein 1 (BAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BRCA1 Associated Protein 1 (BAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for BRCA1 Associated Protein 1 (BAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BRCA1 Associated Protein 1 (BAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BRCA1 Associated Protein 1 (BAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BRCA1 Associated Protein 1 (BAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BRCA1 Associated Protein 1 (BAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for BRCA1 Associated Protein 1 (BAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BRCA1 Associated Protein 1 (BAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BRCA1 Associated Protein 1 (BAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BRCA1 Associated Protein 1 (BAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BRCA1 Associated Protein 1 (BAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for BRCA1 Associated Protein 1 (BAP1) ELISA Kit Customized Service Offer
  1. "BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression."Oncogene 16:1097-1112(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries."Int. J. Cancer 106:244-251(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma."Nat. Genet. 43:668-672(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Germline mutations in BAP1 predispose to melanocytic tumors." Nat. Genet. 43:1018-1021(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Germline BAP1 mutations predispose to malignant mesothelioma."Nat. Genet. 43:1022-1025(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Defining biochemical functions for the BRCA1 tumor suppressor protein: analysis of the BRCA1 binding protein BAP1."Cancer Lett. 143:S13-S17(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains."EMBO J. 21:6755-6762(2002) [PubMed] [Europe PMC] [Abstract]
  17. "BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization."Cancer Res. 68:6953-6962(2008) [PubMed] [Europe PMC] [Abstract]
  18. "BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity."Cancer Res. 69:111-119(2009) [PubMed] [Europe PMC] [Abstract]
  19. "The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1."J. Biol. Chem. 284:34179-34188(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1."Mol. Cell. Biol. 29:2181-2192(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB."Nature 465:243-247(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O."Mol. Cell 54:392-406(2014) [PubMed] [Europe PMC] [Abstract]