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Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2)

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B3GN-T1; B3GN-T2; B3GNT; B3GNT1; BETA3GNT; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2; UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 7

Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2)
CCC J575
HGNC 15629
MGI 1889505
PubMed 20816167
RGD 1310077
UniProt Q9NY97
Wiki B3GNT2
b3GNT2 is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. The protein, 83% identical and 90% similar to the 325-amino acid mouse sequence, has a potential 19-residue N-terminal type II transmembrane domain with a number of conserved motifs but distinct locations of the cys residues.Functional analysis showed that B3GNT has a marked preference for Gal(beta1-4)GlcNAc-based acceptors, whereas it has no activity on type-1 Gal(beta1-3)GlcNAc or O-glycan core-1 Gal(beta1-3)GalNAc acceptors.B3GNT could both initiate and elongate poly-N-acetyllactosamine chains, activities that confirmed its identity with poly-N-acetyllactosamine synthase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-1,3-N-Acetylglucosaminyltransferase 2 (b3GNT2) ELISA Kit Customized Service Offer
  1. "A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases."Proc. Natl. Acad. Sci. U.S.A. 96:406-411(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family."J. Biol. Chem. 276:3498-3507(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions."Biochim. Biophys. Acta 1473:35-53(1999) [PubMed] [Europe PMC] [Abstract]
  7. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells."J. Biol. Chem. 283:33094-33100(2008) [PubMed] [Europe PMC] [Abstract]
  10. "B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of alpha-dystroglycan."Elife 3:0-0(2014) [PubMed] [Europe PMC] [Abstract]