Actin Related Protein 2/3 Complex Subunit 4 (ARPC4)
[Edit]ARC20; p20-Arc; Arp2/3 Protein Complex Subunit p20; Arp2/3 complex 20 kDa subunit
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ARPC4 encodes one of seven subunits of the human Arp2/3 protein complex.The exact role of the protein encoded by this gene, the p20 subunit, has yet to be determined. Three transcript variants encoding two distinct isoforms have been found for this gene. The ARC20 cDNA encodes a deduced 168-amino acid protein that is 68% and 67% identical to its homologs in S. pombe and S. cerevisiae, respectively.
Asymmetric, oblate ellipsoids were revealed. Image analysis of actin branches indicated that the complex binds the side of the mother filament, and ARP2 and ARP3 are the first 2 subunits of the daughter filament. Comparison to the actin-free WASP-activated complexes suggests that branch initiation involves large-scale structural rearrangements within ARP2/3.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPJ599Hu01 | Recombinant Actin Related Protein 2/3 Complex Subunit 4 (ARPC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAJ599Hu01 | Polyclonal Antibody to Actin Related Protein 2/3 Complex Subunit 4 (ARPC4) | WB; IHC |
| Assay Kits | n/a | CLIA Kit for Actin Related Protein 2/3 Complex Subunit 4 (ARPC4) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Actin Related Protein 2/3 Complex Subunit 4 (ARPC4) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPJ599Mu01 | Recombinant Actin Related Protein 2/3 Complex Subunit 4 (ARPC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPJ599Mu02 | Recombinant Actin Related Protein 2/3 Complex Subunit 4 (ARPC4) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAJ599Mu01 | Polyclonal Antibody to Actin Related Protein 2/3 Complex Subunit 4 (ARPC4) | WB; IHC; ICC; IP. |
| PAJ599Mu02 | Polyclonal Antibody to Actin Related Protein 2/3 Complex Subunit 4 (ARPC4) | WB; IHC; ICC; IP. | |
| Assay Kits | SEJ599Mu | ELISA Kit for Actin Related Protein 2/3 Complex Subunit 4 (ARPC4) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPJ599Ra01 | Recombinant Actin Related Protein 2/3 Complex Subunit 4 (ARPC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAJ599Ra01 | Polyclonal Antibody to Actin Related Protein 2/3 Complex Subunit 4 (ARPC4) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Actin Related Protein 2/3 Complex Subunit 4 (ARPC4) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Actin Related Protein 2/3 Complex Subunit 4 (ARPC4) | ELISA Kit Customized Service Offer |
- "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins."Biochem. J. 328:105-112(1997) [PubMed] [Europe PMC] [Abstract]
- "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly."J. Cell Biol. 138:375-384(1997) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
- "Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity."Mol. Cell 8:1041-1052(2001) [PubMed] [Europe PMC] [Abstract]