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Androgen Induced Proliferation Inhibitor (APRIN)

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PDS5B; AS3; PDS5,Regulator Of Cohesion Maintenance B; Sister chromatid cohesion protein PDS5B; Androgen-induced prostate proliferative shutoff-associated protein AS3

Androgen Induced Proliferation Inhibitor (APRIN)
CCC J624
HGNC 20418
MGI 2140945
PubMed 8812419
RGD 1310838
UniProt Q9NTI5
Wiki PDS5B
In the prostate of adult mammals, most epithelial cells are in a state of proliferative quiescence. Androgens regulate this effect by inducing cell cycle arrest in the G0/G1 phase. The expression pattern of one of these sequences, designated AS3, strongly correlated with the expression of the androgen-induced proliferative shutoff both temporally and dosewise. The AS3 gene is upregulated during androgen-induced proliferative shutoff and induces cell proliferation arrest when expressed in a retrovirus transduced model. The deduced 1,391-amino acid AS3 protein has putative transactivating features, protein-protein interaction motifs (coiled coil and leucine zipper), and DNA-binding domains, suggesting that AS3 is a transcription factor. AS3 also has a protein-kinase motif, suggesting that it may act by phosphorylating a target protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Androgen Induced Proliferation Inhibitor (APRIN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Androgen Induced Proliferation Inhibitor (APRIN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Androgen Induced Proliferation Inhibitor (APRIN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Androgen Induced Proliferation Inhibitor (APRIN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Androgen Induced Proliferation Inhibitor (APRIN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Androgen Induced Proliferation Inhibitor (APRIN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Androgen Induced Proliferation Inhibitor (APRIN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Androgen Induced Proliferation Inhibitor (APRIN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Androgen Induced Proliferation Inhibitor (APRIN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Androgen Induced Proliferation Inhibitor (APRIN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Androgen Induced Proliferation Inhibitor (APRIN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Androgen Induced Proliferation Inhibitor (APRIN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Androgen Induced Proliferation Inhibitor (APRIN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Androgen Induced Proliferation Inhibitor (APRIN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Androgen Induced Proliferation Inhibitor (APRIN) ELISA Kit Customized Service Offer
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  20. "Sororin mediates sister chromatid cohesion by antagonizing wapl."Cell 143:737-749(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]