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Translocator Protein (TSPO)

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IBP; PKBS; PBR; pk18; mDRC; MBR; BZRP; DBI; PTBR; Mitochondrial benzodiazepine receptor; Peripheral-Type Benzodiazepine Receptor/Recognition Site

Translocator Protein (TSPO)
CCC J628
HGNC 1158
MGI 88222
PubMed 21498529
RGD 2228
UniProt P30536
Wiki TSPO
TSPO) is an 18 kDa protein of the outer mitochondrial membrane. It was a secondary binding site for diazepam, but subsequent research has found the receptor to be expressed throughout the body and brain.
TSPO has been shown to be involved in a number of processes such as inflammation, and TSPO ligands may be useful anti-cancer drugs. Activation of TSPO is also required for steroidogenesis to take place, and this is particularly important for the production of neuroactive steroids such as allopregnanolone in the brain. This makes some TSPO ligands such as emapunil (XBD-173) useful as potential anxiolytics which may have less side effects than traditional benzodiazepine-type drugs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ628Hu01 Recombinant Translocator Protein (TSPO) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ628Hu02 Recombinant Translocator Protein (TSPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ628Hu01 Polyclonal Antibody to Translocator Protein (TSPO) WB; IHC; ICC; IP.
MAJ628Hu21 Monoclonal Antibody to Translocator Protein (TSPO) WB; IHC; ICC; IP.
Assay Kits SEJ628Hu ELISA Kit for Translocator Protein (TSPO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Translocator Protein (TSPO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Translocator Protein (TSPO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Translocator Protein (TSPO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Translocator Protein (TSPO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Translocator Protein (TSPO) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Translocator Protein (TSPO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Translocator Protein (TSPO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Translocator Protein (TSPO) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ628Ra ELISA Kit for Translocator Protein (TSPO) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Comparison of repetitive elements in the third intron of human and rodent mitochondrial benzodiazepine receptor-encoding genes."Gene 155:201-205(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells."Mol. Pharmacol. 69:37-44(2006) [PubMed] [Europe PMC] [Abstract]
  4. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
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  8. "Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function."Trends Pharmacol. Sci. 27:402-409(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers."Int. J. Oncol. 30:81-89(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states."Mol. Cell. Endocrinol. 327:1-12(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Targeting mitochondrial 18kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype."Clin. Sci. 127:603-613(2014) [PubMed] [Europe PMC] [Abstract]
  13. "An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample."J. Neural Transm. 107:491-500(2000) [PubMed] [Europe PMC] [Abstract]
  14. "No association of two missense variations of the benzodiazepine receptor (peripheral) gene and mood disorders in a Japanese sample."Am. J. Med. Genet. 105:172-175(2001) [PubMed] [Europe PMC] [Abstract]
  15. "The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals."Endocrinology 150:5438-5445(2009) [PubMed] [Europe PMC] [Abstract]