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N-Acylaminoacyl Peptide Hydrolase (APEH)

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ACPH; APH; OPH; Acyl-peptide hydrolase; Acylaminoacyl-peptidase; Oxidized protein hydrolase

N-Acylaminoacyl Peptide Hydrolase (APEH)
CCC J633
HGNC 586
MGI 88041
PubMed 2392324
RGD 2125
UniProt P13798
Wiki APEH
APEH encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Acylaminoacyl Peptide Hydrolase (APEH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Acylaminoacyl Peptide Hydrolase (APEH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Acylaminoacyl Peptide Hydrolase (APEH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Acylaminoacyl Peptide Hydrolase (APEH) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Acylaminoacyl Peptide Hydrolase (APEH) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Acylaminoacyl Peptide Hydrolase (APEH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Acylaminoacyl Peptide Hydrolase (APEH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Acylaminoacyl Peptide Hydrolase (APEH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Acylaminoacyl Peptide Hydrolase (APEH) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Acylaminoacyl Peptide Hydrolase (APEH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Acylaminoacyl Peptide Hydrolase (APEH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Acylaminoacyl Peptide Hydrolase (APEH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Acylaminoacyl Peptide Hydrolase (APEH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Acylaminoacyl Peptide Hydrolase (APEH) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Acylaminoacyl Peptide Hydrolase (APEH) ELISA Kit Customized Service Offer
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  2. "Identification of oxidized protein hydrolase of human erythrocytes as acylpeptide hydrolase."Biochim. Biophys. Acta 1478:102-112(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNF15S2 locus at 3p21 is transcribed in normal lung and small cell lung cancer."Genomics 4:355-361(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Structural investigations on human erythrocyte acylpeptide hydrolase by mass spectrometric procedures."J. Protein Chem. 18:349-360(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase."Oncogene 6:1293-1295(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities."Proc. Natl. Acad. Sci. U.S.A. 88:2194-2198(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme."J. Biol. Chem. 267:3811-3818(1992) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Crystallization and preliminary X-ray studies of human erythrocyte acylpeptide hydrolase."J. Mol. Biol. 233:546-549(1993) [PubMed] [Europe PMC] [Abstract]