Acidic Nuclear Phosphoprotein 32 Family, Member D (ANP32D)

Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene. This gene does not contain introns.

ANP32C and ANP32D were able to stimulate transformed focus formation when cotransfected into NIH 3T3 cells along with tumor promoters. NIH 3T3 cells transformed with ANP32C or ANP32D were also tumorigenic in nude mice.