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Aminomethyltransferase (AMT)

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GCST; NKH; GCVT; Glycine Cleavage System Protein T

Aminomethyltransferase (AMT)
CCC J643
HGNC 473
MGI 3646700
PubMed 20375021
RGD 1359408
UniProt P48728
Wiki AMT
Aminomethyltransferase is an enzyme that catabolizes the creation of methylenetetrahydrofolate. It is part of the Glycine decarboxylase complex.
The enzyme system for cleavage of glycine (glycine cleavage system; EC 2.1.2.10), which is confined to the mitochondria, is composed of 4 protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). Glycine encephalopathy (GCE) may be due to a defect in any one of these enzymes.the structure and expression of the glycine cleavage system in rat central nervous system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aminomethyltransferase (AMT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aminomethyltransferase (AMT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aminomethyltransferase (AMT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aminomethyltransferase (AMT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aminomethyltransferase (AMT) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aminomethyltransferase (AMT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aminomethyltransferase (AMT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aminomethyltransferase (AMT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aminomethyltransferase (AMT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aminomethyltransferase (AMT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aminomethyltransferase (AMT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aminomethyltransferase (AMT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aminomethyltransferase (AMT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aminomethyltransferase (AMT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aminomethyltransferase (AMT) ELISA Kit Customized Service Offer
  1. "Isolation and sequence determination of cDNA encoding human T-protein of the glycine cleavage system."Biochem. Biophys. Res. Commun. 192:766-771(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and chromosomal localization of the aminomethyltransferase gene (AMT)."Genomics 19:27-30(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia."J. Mol. Biol. 351:1146-1159(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of the mutations in the T-protein gene causing typical and atypical nonketotic hyperglycinemia."Hum. Genet. 93:655-658(1994) [PubMed] [Europe PMC] [Abstract]
  9. "A missense mutation (His42Arg) in the T-protein gene from a large Israeli-Arab kindred with nonketotic hyperglycinemia."Hum. Genet. 102:430-434(1998) [PubMed] [Europe PMC] [Abstract]
  10. "A one-base deletion (183delC) and a missense mutation (D276H) in the T-protein gene from a Japanese family with nonketotic hyperglycinemia."J. Hum. Genet. 43:135-137(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Biochemical and molecular investigations of patients with nonketotic hyperglycinemia."Mol. Genet. Metab. 70:116-121(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Recurrent mutations in P- and T-proteins of the glycine cleavage complex and a novel T-protein mutation (N145I): a strategy for the molecular investigation of patients with nonketotic hyperglycinemia (NKH)."Mol. Genet. Metab. 72:322-325(2001) [PubMed] [Europe PMC] [Abstract]