The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. AKTIP may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant AKT Interacting Protein (AKTIP) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to AKT Interacting Protein (AKTIP) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to AKT Interacting Protein (AKTIP) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for AKT Interacting Protein (AKTIP) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for AKT Interacting Protein (AKTIP) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant AKT Interacting Protein (AKTIP) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to AKT Interacting Protein (AKTIP) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to AKT Interacting Protein (AKTIP) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for AKT Interacting Protein (AKTIP) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for AKT Interacting Protein (AKTIP) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant AKT Interacting Protein (AKTIP) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to AKT Interacting Protein (AKTIP) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to AKT Interacting Protein (AKTIP) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for AKT Interacting Protein (AKTIP) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for AKT Interacting Protein (AKTIP) | ELISA Kit Customized Service Offer |
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt."Mol. Cell. Biol. 24:1493-1504(2004) [PubMed] [Europe PMC] [Abstract]
- "An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex."Mol. Biol. Cell 19:5059-5071(2008) [PubMed] [Europe PMC] [Abstract]