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Aldo Keto Reductase Family 1, Member B1 (AKR1B1)

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ADR; ALDR1; AR; Aldose Reductase

Aldo Keto Reductase Family 1, Member B1 (AKR1B1)
CCC J656
HGNC 381
MGI 1353494
PubMed 22654757
RGD 2092
UniProt P15121
Wiki AKR1B1
AKR1B1encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. The deduced amino acid sequence indicated that maturation of aldose reductase involves removal of the N-terminal methionine.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aldo Keto Reductase Family 1, Member B1 (AKR1B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aldo Keto Reductase Family 1, Member B1 (AKR1B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aldo Keto Reductase Family 1, Member B1 (AKR1B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aldo Keto Reductase Family 1, Member B1 (AKR1B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldo Keto Reductase Family 1, Member B1 (AKR1B1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aldo Keto Reductase Family 1, Member B1 (AKR1B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aldo Keto Reductase Family 1, Member B1 (AKR1B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aldo Keto Reductase Family 1, Member B1 (AKR1B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aldo Keto Reductase Family 1, Member B1 (AKR1B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldo Keto Reductase Family 1, Member B1 (AKR1B1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aldo Keto Reductase Family 1, Member B1 (AKR1B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aldo Keto Reductase Family 1, Member B1 (AKR1B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aldo Keto Reductase Family 1, Member B1 (AKR1B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aldo Keto Reductase Family 1, Member B1 (AKR1B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldo Keto Reductase Family 1, Member B1 (AKR1B1) ELISA Kit Customized Service Offer
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  14. , Submitted (MAR-2007) to UniProtKB
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  16. "Sequence of pig lens aldose reductase and electrospray mass spectrometry of non-covalent and covalent complexes."Eur. J. Biochem. 218:893-903(1993) [PubMed] [Europe PMC] [Abstract]
  17. "Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110."J. Biol. Chem. 268:25687-25693(1993) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications."Science 257:81-84(1992) [PubMed] [Europe PMC] [Abstract]
  22. "The crystal structure of the aldose reductase.NADPH binary complex."J. Biol. Chem. 267:24841-24847(1992) [PubMed] [Europe PMC] [Abstract]
  23. "Refined 1.8-A structure of human aldose reductase complexed with the potent inhibitor zopolrestat."Proc. Natl. Acad. Sci. U.S.A. 90:9847-9851(1993) [PubMed] [Europe PMC] [Abstract]
  24. "The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant."Biochemistry 36:16134-16140(1997) [PubMed] [Europe PMC] [Abstract]
  25. "The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48."Acta Crystallogr. D 60:1347-1354(2004) [PubMed] [Europe PMC] [Abstract]
  26. "Ultrahigh resolution drug design I: details of interactions in human aldose reductase-inhibitor complex at 0.66 A."Proteins 55:792-804(2004) [PubMed] [Europe PMC] [Abstract]
  27. "High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group."J. Mol. Biol. 356:45-56(2006) [PubMed] [Europe PMC] [Abstract]
  28. "The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop."Acta Crystallogr. D 63:665-672(2007) [PubMed] [Europe PMC] [Abstract]
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  30. "Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution."J. Mol. Biol. 368:618-638(2007) [PubMed] [Europe PMC] [Abstract]