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Aldo Keto Reductase Family 1, Member A1 (AKR1A1)

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ALDR1; ALR; DD3; Aldehyde Reductase; Dihydrodiol Dehydrogenase 3; Alcohol dehydrogenase [NADP(+)]

Aldo Keto Reductase Family 1, Member A1 (AKR1A1)
CCC J657
HGNC 380
MGI 1929955
PubMed 10393438
RGD 68346
UniProt P14550
Wiki AKR1A1
AKR1A1 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Alternative splicing of this gene results in two transcript variants encoding the same protein. Lens aldose reductase is composed of a single subunit with molecular weight 35 kD, and liver aldehyde reductase is composed of a single subunit of molecular weight 32 kD. Liver aldose reductase M is composed of 2 nonidentical subunits of molecular weights 35 kD and 42 kD. Lens has only AR, liver has ARM and ALR, red cells have only ALR, while brain and placenta have all 3 enzymes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aldo Keto Reductase Family 1, Member A1 (AKR1A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aldo Keto Reductase Family 1, Member A1 (AKR1A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aldo Keto Reductase Family 1, Member A1 (AKR1A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aldo Keto Reductase Family 1, Member A1 (AKR1A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldo Keto Reductase Family 1, Member A1 (AKR1A1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aldo Keto Reductase Family 1, Member A1 (AKR1A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aldo Keto Reductase Family 1, Member A1 (AKR1A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aldo Keto Reductase Family 1, Member A1 (AKR1A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aldo Keto Reductase Family 1, Member A1 (AKR1A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldo Keto Reductase Family 1, Member A1 (AKR1A1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aldo Keto Reductase Family 1, Member A1 (AKR1A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aldo Keto Reductase Family 1, Member A1 (AKR1A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aldo Keto Reductase Family 1, Member A1 (AKR1A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aldo Keto Reductase Family 1, Member A1 (AKR1A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldo Keto Reductase Family 1, Member A1 (AKR1A1) ELISA Kit Customized Service Offer
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  2. "The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33-->p32."Cytogenet. Cell Genet. 84:230-232(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the human aldehyde reductase gene and promoter."Genomics 60:188-198(1999) [PubMed] [Europe PMC] [Abstract]
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  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
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  7. "Primary structure of aldehyde reductase from human liver."Prog. Clin. Biol. Res. 232:297-307(1987) [PubMed] [Europe PMC] [Abstract]
  8. "Mechanism of human aldehyde reductase: characterization of the active site pocket."Biochemistry 34:11264-11275(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members."Biochem. J. 343:487-504(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1)."Chem. Biol. Interact. 130:815-824(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Two allelic variants of aldo-keto reductase 1A1 exhibit reduced in vitro metabolism of daunorubicin."Drug Metab. Dispos. 36:904-910(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications."Acta Crystallogr. D 50:859-868(1994) [PubMed] [Europe PMC] [Abstract]