≡

Aryl Hydrocarbon Receptor Repressor (AHRR)

[Edit]

AHH; AHHR; BHLHE77; Aryl Hydrocarbon Receptor Regulator; Class E basic helix-loop-helix protein 77

Aryl Hydrocarbon Receptor Repressor (AHRR)
CCC J660
HGNC 346
MGI 1333776
PubMed 22337624
RGD 1559857
UniProt Q9ULI6
Wiki AHRR
AHRR represses signal transduction by the arylhydrocarbon receptor by competing with the arylhydrocarbon receptor nuclear translocator for binding to the arylhydrocarbon receptor. Expression of the repressor is stimulated by the receptor/translocator heterodimer, thereby regulating receptor function through a negative feedback mechanism. In addition, the encoded protein can bind to nuclear factor kappa-B.
Mouse Ahrr inhibited Ahr function by competing with Ahr for dimerizing with Arnt and binding to the XRE. expression of Ahrr was induced by the Ahr-Arnt heterodimer when the latter bound to the XRE of Ahrr, i.e., Ahrr regulated Ahr function by negative feedback and affected expression of target genes induced by dioxin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ660Hu01 Recombinant Aryl Hydrocarbon Receptor Repressor (AHRR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ660Hu01 Polyclonal Antibody to Aryl Hydrocarbon Receptor Repressor (AHRR) WB
MAJ660Hu21 Monoclonal Antibody to Aryl Hydrocarbon Receptor Repressor (AHRR) WB; IHC; ICC; IP.
Assay Kits SEJ660Hu ELISA Kit for Aryl Hydrocarbon Receptor Repressor (AHRR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aryl Hydrocarbon Receptor Repressor (AHRR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aryl Hydrocarbon Receptor Repressor (AHRR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aryl Hydrocarbon Receptor Repressor (AHRR) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ660Mu ELISA Kit for Aryl Hydrocarbon Receptor Repressor (AHRR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aryl Hydrocarbon Receptor Repressor (AHRR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aryl Hydrocarbon Receptor Repressor (AHRR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aryl Hydrocarbon Receptor Repressor (AHRR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aryl Hydrocarbon Receptor Repressor (AHRR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aryl Hydrocarbon Receptor Repressor (AHRR) ELISA Kit Customized Service Offer
  1. "Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis."Teratology 65:10-18(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells."Life Sci. 74:1039-1049(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of intracellular localization signals and of mechanisms underlining the nucleocytoplasmic shuttling of human aryl hydrocarbon receptor repressor."Biochem. Biophys. Res. Commun. 364:1026-1031(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines."Drug Metab. Dispos. 35:2262-2269(2007) [PubMed] [Europe PMC] [Abstract]
  8. "The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers."J. Clin. Invest. 118:640-650(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene: implication for the susceptibility to dioxins."Fertil. Steril. 82:1067-1071(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity."Fertil. Steril. 84:454-458(2005) [PubMed] [Europe PMC] [Abstract]
  11. "The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility."Fertil. Steril. 88:854-859(2007) [PubMed] [Europe PMC] [Abstract]